Cytoprotective effects of ginsenosides.
Carlos Fernández-Moriano
Elena González-Burgos
Irene Iglesias
Rafael Lozano
M. Pilar Gómez-Serranillos
10.1371/journal.pone.0182933.g002
https://plos.figshare.com/articles/figure/Cytoprotective_effects_of_ginsenosides_/5315836
<p>(A) Cytoprotective effects of six ginsenosides in SH-SY5Y cell line against rotenone-mediated toxicity (range of concentrations: 0.5–10 μM), assessed by MTT reduction assay. Cells were pre-treated with ginsenosides for 24 h and then exposed to rotenone 50 μM for other 24 h. The viability of control cells was normalized to 100%. Means ± SD, * p < 0.05 Vs control, # p < 0.05 Vs rotenone. (B) Representative images of the morphological studies conducted on SH-SY5Y cell model with ginsenosides Rb1 and Rg1.</p>
2017-08-16 17:30:34
Nrf 2 pathway activation
Bcl -2 expressions
SH-SY 5Y cells
ameliorated redox status
Methods Oxidative stress
ROS
ginsenosides Rb 1
lipid peroxidation levels
mitochondrial
apoptotic cell death
calcium homeostasis disruption
SOD activity
model Background Ginseng
MMP
Rg 1 exhibit neuroprotective
blood brain barrier
oxidative stress-mediated neurotoxicity
Rg 1
TBARS
Nrf 2 activation
Poor BBB permeation