Cytoprotective effects of ginsenosides. Carlos Fernández-Moriano Elena González-Burgos Irene Iglesias Rafael Lozano M. Pilar Gómez-Serranillos 10.1371/journal.pone.0182933.g002 https://plos.figshare.com/articles/figure/Cytoprotective_effects_of_ginsenosides_/5315836 <p>(A) Cytoprotective effects of six ginsenosides in SH-SY5Y cell line against rotenone-mediated toxicity (range of concentrations: 0.5–10 μM), assessed by MTT reduction assay. Cells were pre-treated with ginsenosides for 24 h and then exposed to rotenone 50 μM for other 24 h. The viability of control cells was normalized to 100%. Means ± SD, * p < 0.05 Vs control, # p < 0.05 Vs rotenone. (B) Representative images of the morphological studies conducted on SH-SY5Y cell model with ginsenosides Rb1 and Rg1.</p> 2017-08-16 17:30:34 Nrf 2 pathway activation Bcl -2 expressions SH-SY 5Y cells ameliorated redox status Methods Oxidative stress ROS ginsenosides Rb 1 lipid peroxidation levels mitochondrial apoptotic cell death calcium homeostasis disruption SOD activity model Background Ginseng MMP Rg 1 exhibit neuroprotective blood brain barrier oxidative stress-mediated neurotoxicity Rg 1 TBARS Nrf 2 activation Poor BBB permeation