Vochyánová, Zora Pokorná, Marie Rotrekl, Dominik Smékal, Václav Fictum, Petr Suchý, Pavel Gajdziok, Jan Šmejkal, Karel Hošek, Jan Effect of a 5-day treatment with morusin B (in mg/kg) on the activity of matrix metalloproteinases in TNBS-induced colitis, compared to the intact group, the untreated group (CTRL), and the group treated with sulfasalazine 50 mg/kg (SAS). <p>(A) MMP9 activity, (B) total MMP2 activity, (C) activity of the pro-form of MMP2, (D) activity of the mature form of MMP2, (E) pro-MMP2/MMP2 ratio. The activity of MMPs was detected by zymography, quantified by densitometry, and normalized to a standard control (1% FBS). A representative zymogram is shown (F). The results are expressed as the mean, with error bars representing SEM. CTRL vs. intact group: ## <i>p</i> < 0.01, ### <i>p</i> < 0.001, #### <i>p</i> < 0.0001; CTRL vs. treated groups: ** <i>p</i> < 0.01, *** <i>p</i> < 0.001, **** <i>p</i> < 0.0001.</p> MMP 2;superoxide dismutase;dose;zymographic analysis;TGF -β1 levels;tissue damage scores;root bark;Morus alba;TNBS-induced colitis;rats Morusin;growth factor;Prenylated flavonoid morusin;anti-inflammatory agents;mg;sulfasalazine;Wistar rats;SOD;IL -1β.;Many studies;matrix metalloproteinases;antioxidant enzymes;MMP 9 activities;prenylated flavonoid;bowel disease 2017-08-10
    https://plos.figshare.com/articles/figure/Effect_of_a_5-day_treatment_with_morusin_B_in_mg_kg_on_the_activity_of_matrix_metalloproteinases_in_TNBS-induced_colitis_compared_to_the_intact_group_the_untreated_group_CTRL_and_the_group_treated_with_sulfasalazine_50_mg_kg_SAS_/5300716
10.1371/journal.pone.0182464.g005