%0 Figure %A Vochyánová, Zora %A Pokorná, Marie %A Rotrekl, Dominik %A Smékal, Václav %A Fictum, Petr %A Suchý, Pavel %A Gajdziok, Jan %A Šmejkal, Karel %A Hošek, Jan %D 2017 %T Effect of a 5-day treatment with morusin B (in mg/kg) on the activity of matrix metalloproteinases in TNBS-induced colitis, compared to the intact group, the untreated group (CTRL), and the group treated with sulfasalazine 50 mg/kg (SAS). %U https://plos.figshare.com/articles/figure/Effect_of_a_5-day_treatment_with_morusin_B_in_mg_kg_on_the_activity_of_matrix_metalloproteinases_in_TNBS-induced_colitis_compared_to_the_intact_group_the_untreated_group_CTRL_and_the_group_treated_with_sulfasalazine_50_mg_kg_SAS_/5300716 %R 10.1371/journal.pone.0182464.g005 %2 https://plos.figshare.com/ndownloader/files/9087310 %K MMP 2 %K superoxide dismutase %K dose %K zymographic analysis %K TGF -β1 levels %K tissue damage scores %K root bark %K Morus alba %K TNBS-induced colitis %K rats Morusin %K growth factor %K Prenylated flavonoid morusin %K anti-inflammatory agents %K mg %K sulfasalazine %K Wistar rats %K SOD %K IL -1β. %K Many studies %K matrix metalloproteinases %K antioxidant enzymes %K MMP 9 activities %K prenylated flavonoid %K bowel disease %X

(A) MMP9 activity, (B) total MMP2 activity, (C) activity of the pro-form of MMP2, (D) activity of the mature form of MMP2, (E) pro-MMP2/MMP2 ratio. The activity of MMPs was detected by zymography, quantified by densitometry, and normalized to a standard control (1% FBS). A representative zymogram is shown (F). The results are expressed as the mean, with error bars representing SEM. CTRL vs. intact group: ## p < 0.01, ### p < 0.001, #### p < 0.0001; CTRL vs. treated groups: ** p < 0.01, *** p < 0.001, **** p < 0.0001.

%I PLOS ONE