10.1371/journal.pone.0182464.g005 Zora Vochyánová Zora Vochyánová Marie Pokorná Marie Pokorná Dominik Rotrekl Dominik Rotrekl Václav Smékal Václav Smékal Petr Fictum Petr Fictum Pavel Suchý Pavel Suchý Jan Gajdziok Jan Gajdziok Karel Šmejkal Karel Šmejkal Jan Hošek Jan Hošek Effect of a 5-day treatment with morusin B (in mg/kg) on the activity of matrix metalloproteinases in TNBS-induced colitis, compared to the intact group, the untreated group (CTRL), and the group treated with sulfasalazine 50 mg/kg (SAS). Public Library of Science 2017 MMP 2 superoxide dismutase dose zymographic analysis TGF -β1 levels tissue damage scores root bark Morus alba TNBS-induced colitis rats Morusin growth factor Prenylated flavonoid morusin anti-inflammatory agents mg sulfasalazine Wistar rats SOD IL -1β. Many studies matrix metalloproteinases antioxidant enzymes MMP 9 activities prenylated flavonoid bowel disease 2017-08-10 18:10:19 Figure https://plos.figshare.com/articles/figure/Effect_of_a_5-day_treatment_with_morusin_B_in_mg_kg_on_the_activity_of_matrix_metalloproteinases_in_TNBS-induced_colitis_compared_to_the_intact_group_the_untreated_group_CTRL_and_the_group_treated_with_sulfasalazine_50_mg_kg_SAS_/5300716 <p>(A) MMP9 activity, (B) total MMP2 activity, (C) activity of the pro-form of MMP2, (D) activity of the mature form of MMP2, (E) pro-MMP2/MMP2 ratio. The activity of MMPs was detected by zymography, quantified by densitometry, and normalized to a standard control (1% FBS). A representative zymogram is shown (F). The results are expressed as the mean, with error bars representing SEM. CTRL vs. intact group: ## <i>p</i> < 0.01, ### <i>p</i> < 0.001, #### <i>p</i> < 0.0001; CTRL vs. treated groups: ** <i>p</i> < 0.01, *** <i>p</i> < 0.001, **** <i>p</i> < 0.0001.</p>