10.1371/journal.pone.0182464.g005
Zora Vochyánová
Zora
Vochyánová
Marie Pokorná
Marie
Pokorná
Dominik Rotrekl
Dominik
Rotrekl
Václav Smékal
Václav
Smékal
Petr Fictum
Petr
Fictum
Pavel Suchý
Pavel
Suchý
Jan Gajdziok
Jan
Gajdziok
Karel Šmejkal
Karel
Šmejkal
Jan Hošek
Jan
Hošek
Effect of a 5-day treatment with morusin B (in mg/kg) on the activity of matrix metalloproteinases in TNBS-induced colitis, compared to the intact group, the untreated group (CTRL), and the group treated with sulfasalazine 50 mg/kg (SAS).
Public Library of Science
2017
MMP 2
superoxide dismutase
dose
zymographic analysis
TGF -β1 levels
tissue damage scores
root bark
Morus alba
TNBS-induced colitis
rats Morusin
growth factor
Prenylated flavonoid morusin
anti-inflammatory agents
mg
sulfasalazine
Wistar rats
SOD
IL -1β.
Many studies
matrix metalloproteinases
antioxidant enzymes
MMP 9 activities
prenylated flavonoid
bowel disease
2017-08-10 18:10:19
Figure
https://plos.figshare.com/articles/figure/Effect_of_a_5-day_treatment_with_morusin_B_in_mg_kg_on_the_activity_of_matrix_metalloproteinases_in_TNBS-induced_colitis_compared_to_the_intact_group_the_untreated_group_CTRL_and_the_group_treated_with_sulfasalazine_50_mg_kg_SAS_/5300716
<p>(A) MMP9 activity, (B) total MMP2 activity, (C) activity of the pro-form of MMP2, (D) activity of the mature form of MMP2, (E) pro-MMP2/MMP2 ratio. The activity of MMPs was detected by zymography, quantified by densitometry, and normalized to a standard control (1% FBS). A representative zymogram is shown (F). The results are expressed as the mean, with error bars representing SEM. CTRL vs. intact group: ## <i>p</i> < 0.01, ### <i>p</i> < 0.001, #### <i>p</i> < 0.0001; CTRL vs. treated groups: ** <i>p</i> < 0.01, *** <i>p</i> < 0.001, **** <i>p</i> < 0.0001.</p>