Sayama, Koji Kajiya, Kentaro Sugawara, Koji Sato, Shintaro Hirakawa, Satoshi Shirakata, Yuji Hanakawa, Yasushi Dai, Xiuju Ishimatsu-Tsuji, Yumiko Metzger, Daniel Chambon, Pierre Akira, Shizuo Paus, Ralf Kishimoto, Jiro Hashimoto, Koji Keratinocyte-specific TAK1 deletion delays hair cycle progression in adolescent mice. <p>(A) Schedule of tamoxifen application. The hair cycle was synchronized to anagen phase by wax depilation, and tamoxifen was topically applied to the dorsal skin of <i>Map3k7</i><sup>fl/fl</sup>K14-Cre-ER<sup>T2</sup>mice to delete TAK1. As controls, <i>Map3k7</i><sup>fl/fl</sup> mice or <i>Map3k7</i><sup>fl/fl</sup>K14-Cre-ER<sup>T2</sup> mice were treated with tamoxifen or ethanol, respectively. (B) Clinical appearance at the indicated time point after the depilation. At 2 weeks, hair shaft formation was noted in the control mice, while hair shaft growth was not seen in the tamoxifen-treated <i>Map3k7</i><sup>fl/fl</sup>K14-Cre-ER<sup>T2</sup> mice. (C) Histological analysis at the indicated time point after the depilation. Anagen progression was severely delayed in TAK1-deleted mice at 1–3 weeks. Scale bar, 100 µm.</p> tak1;deletion;delays;progression 2013-02-21
    https://plos.figshare.com/articles/figure/_Keratinocyte_specific_TAK1_deletion_delays_hair_cycle_progression_in_adolescent_mice_/514165
10.1371/journal.pone.0011275.g004