%0 Figure %A Sayama, Koji %A Kajiya, Kentaro %A Sugawara, Koji %A Sato, Shintaro %A Hirakawa, Satoshi %A Shirakata, Yuji %A Hanakawa, Yasushi %A Dai, Xiuju %A Ishimatsu-Tsuji, Yumiko %A Metzger, Daniel %A Chambon, Pierre %A Akira, Shizuo %A Paus, Ralf %A Kishimoto, Jiro %A Hashimoto, Koji %D 2013 %T Keratinocyte-specific TAK1 deletion delays hair cycle progression in adolescent mice. %U https://plos.figshare.com/articles/figure/_Keratinocyte_specific_TAK1_deletion_delays_hair_cycle_progression_in_adolescent_mice_/514165 %R 10.1371/journal.pone.0011275.g004 %2 https://plos.figshare.com/ndownloader/files/843727 %K tak1 %K deletion %K delays %K progression %X

(A) Schedule of tamoxifen application. The hair cycle was synchronized to anagen phase by wax depilation, and tamoxifen was topically applied to the dorsal skin of Map3k7fl/flK14-Cre-ERT2mice to delete TAK1. As controls, Map3k7fl/fl mice or Map3k7fl/flK14-Cre-ERT2 mice were treated with tamoxifen or ethanol, respectively. (B) Clinical appearance at the indicated time point after the depilation. At 2 weeks, hair shaft formation was noted in the control mice, while hair shaft growth was not seen in the tamoxifen-treated Map3k7fl/flK14-Cre-ERT2 mice. (C) Histological analysis at the indicated time point after the depilation. Anagen progression was severely delayed in TAK1-deleted mice at 1–3 weeks. Scale bar, 100 µm.

%I PLOS ONE