10.1371/journal.pone.0011275.g004
Koji Sayama
Koji
Sayama
Kentaro Kajiya
Kentaro
Kajiya
Koji Sugawara
Koji
Sugawara
Shintaro Sato
Shintaro
Sato
Satoshi Hirakawa
Satoshi
Hirakawa
Yuji Shirakata
Yuji
Shirakata
Yasushi Hanakawa
Yasushi
Hanakawa
Xiuju Dai
Xiuju
Dai
Yumiko Ishimatsu-Tsuji
Yumiko
Ishimatsu-Tsuji
Daniel Metzger
Daniel
Metzger
Pierre Chambon
Pierre
Chambon
Shizuo Akira
Shizuo
Akira
Ralf Paus
Ralf
Paus
Jiro Kishimoto
Jiro
Kishimoto
Koji Hashimoto
Koji
Hashimoto
Keratinocyte-specific TAK1 deletion delays hair cycle progression in adolescent mice.
Public Library of Science
2013
tak1
deletion
delays
progression
2013-02-21 00:52:25
Figure
https://plos.figshare.com/articles/figure/_Keratinocyte_specific_TAK1_deletion_delays_hair_cycle_progression_in_adolescent_mice_/514165
<p>(A) Schedule of tamoxifen application. The hair cycle was synchronized to anagen phase by wax depilation, and tamoxifen was topically applied to the dorsal skin of <i>Map3k7</i><sup>fl/fl</sup>K14-Cre-ER<sup>T2</sup>mice to delete TAK1. As controls, <i>Map3k7</i><sup>fl/fl</sup> mice or <i>Map3k7</i><sup>fl/fl</sup>K14-Cre-ER<sup>T2</sup> mice were treated with tamoxifen or ethanol, respectively. (B) Clinical appearance at the indicated time point after the depilation. At 2 weeks, hair shaft formation was noted in the control mice, while hair shaft growth was not seen in the tamoxifen-treated <i>Map3k7</i><sup>fl/fl</sup>K14-Cre-ER<sup>T2</sup> mice. (C) Histological analysis at the indicated time point after the depilation. Anagen progression was severely delayed in TAK1-deleted mice at 1–3 weeks. Scale bar, 100 µm.</p>