Mitręga, Katarzyna A. Spałek, Adrianna M. Nożyński, Jerzy Porc, Maurycy Stankiewicz, Magdalena Krzemiński, Tadeusz F. Representative histological findings of myocardial tissue evaluation at 35<sup>th</sup> day post-infarction after long-term oral treatment (6<sup>th</sup>– 35<sup>th</sup> day) with captopril (2 × 25 mg/kg) or M-2 (4 mg/kg) (hematoxylin and eozine-stained). <p>(A) Intact specimen of sham-operated heart, (B-C) Control 0.9% NaCl, (D) DMSO group, (E-F) Captopril group, (G) M-2 group (scanned with 20× objective, bar represents 50–100 μm). </p><p></p><p>(A)</p><p>Closely arranged cardiomyocytes with comparable nuclei. Normal myocardial tissue (magnification 30×).</p><p></p><p>(B)</p><p>Non-uniform cardiomyocytes with enlarged, rounded nuclei suggesting early cardiomyopathic process. Interstitial space contains some lymphocytes (magnification 30×).</p><p></p><p>(C)</p><p>Evident cardiomyopathic pattern with perivascular inflammatory infiltrations composed of lymphocytes and larger macrophages (magnification 30×).</p><p></p><p>(D)</p><p>Myocardial tissue morphology resembles intact group specimens (magnification 30×).</p><p></p><p>(E)</p><p>Typical cardiomyopathic pattern with numerous, dense inflammatory infiltrations with evident histiocytes, lymphocytes and other cells (magnification 30×).</p><p></p><p>(F)</p><p>Advanced cardiomyopathy with present fibrotic focai (magnification 20×).</p><p></p><p>(G)</p><p>Moderate cardiomyopathic pattern with lesser inflammatory infiltrations in comparison to captopril group. Regular fibrotic process (magnification 20×).</p><p></p><p></p> <p></p> <p>Closely arranged cardiomyocytes with comparable nuclei. Normal myocardial tissue (magnification 30×).</p> <p>Non-uniform cardiomyocytes with enlarged, rounded nuclei suggesting early cardiomyopathic process. Interstitial space contains some lymphocytes (magnification 30×).</p> <p>Evident cardiomyopathic pattern with perivascular inflammatory infiltrations composed of lymphocytes and larger macrophages (magnification 30×).</p> <p>Myocardial tissue morphology resembles intact group specimens (magnification 30×).</p> <p>Typical cardiomyopathic pattern with numerous, dense inflammatory infiltrations with evident histiocytes, lymphocytes and other cells (magnification 30×).</p> <p>Advanced cardiomyopathy with present fibrotic focai (magnification 20×).</p> <p>Moderate cardiomyopathic pattern with lesser inflammatory infiltrations in comparison to captopril group. Regular fibrotic process (magnification 20×).</p> heart rate increase;Cardiomyopathy development protection;M -2;preload pressure;M -2 therapy;25 years angiotensin-converting enzyme inhibitors;heart tissue specimens;captopril;M -2.;aortic pressure increase;parameter;flow 2017-06-21
    https://plos.figshare.com/articles/figure/Representative_histological_findings_of_myocardial_tissue_evaluation_at_35_sup_th_sup_day_post-infarction_after_long-term_oral_treatment_6_sup_th_sup_35_sup_th_sup_day_with_captopril_2_25_mg_kg_or_M-2_4_mg_kg_hematoxylin_and_eozine-stained_/5134189
10.1371/journal.pone.0179633.g004