10.1371/journal.pone.0179633.g004
Katarzyna A. Mitręga
Katarzyna A.
Mitręga
Adrianna M. Spałek
Adrianna M.
Spałek
Jerzy Nożyński
Jerzy
Nożyński
Maurycy Porc
Maurycy
Porc
Magdalena Stankiewicz
Magdalena
Stankiewicz
Tadeusz F. Krzemiński
Tadeusz F.
Krzemiński
Representative histological findings of myocardial tissue evaluation at 35<sup>th</sup> day post-infarction after long-term oral treatment (6<sup>th</sup>– 35<sup>th</sup> day) with captopril (2 × 25 mg/kg) or M-2 (4 mg/kg) (hematoxylin and eozine-stained).
Public Library of Science
2017
heart rate increase
Cardiomyopathy development protection
M -2
preload pressure
M -2 therapy
25 years angiotensin-converting enzyme inhibitors
heart tissue specimens
captopril
M -2.
aortic pressure increase
parameter
flow
2017-06-21 17:43:12
Figure
https://plos.figshare.com/articles/figure/Representative_histological_findings_of_myocardial_tissue_evaluation_at_35_sup_th_sup_day_post-infarction_after_long-term_oral_treatment_6_sup_th_sup_35_sup_th_sup_day_with_captopril_2_25_mg_kg_or_M-2_4_mg_kg_hematoxylin_and_eozine-stained_/5134189
<p>(A) Intact specimen of sham-operated heart, (B-C) Control 0.9% NaCl, (D) DMSO group, (E-F) Captopril group, (G) M-2 group (scanned with 20× objective, bar represents 50–100 μm).
</p><p></p><p>(A)</p><p>Closely arranged cardiomyocytes with comparable nuclei. Normal myocardial tissue (magnification 30×).</p><p></p><p>(B)</p><p>Non-uniform cardiomyocytes with enlarged, rounded nuclei suggesting early cardiomyopathic process. Interstitial space contains some lymphocytes (magnification 30×).</p><p></p><p>(C)</p><p>Evident cardiomyopathic pattern with perivascular inflammatory infiltrations composed of lymphocytes and larger macrophages (magnification 30×).</p><p></p><p>(D)</p><p>Myocardial tissue morphology resembles intact group specimens (magnification 30×).</p><p></p><p>(E)</p><p>Typical cardiomyopathic pattern with numerous, dense inflammatory infiltrations with evident histiocytes, lymphocytes and other cells (magnification 30×).</p><p></p><p>(F)</p><p>Advanced cardiomyopathy with present fibrotic focai (magnification 20×).</p><p></p><p>(G)</p><p>Moderate cardiomyopathic pattern with lesser inflammatory infiltrations in comparison to captopril group. Regular fibrotic process (magnification 20×).</p><p></p><p></p>
<p></p> <p>Closely arranged cardiomyocytes with comparable nuclei. Normal myocardial tissue (magnification 30×).</p> <p>Non-uniform cardiomyocytes with enlarged, rounded nuclei suggesting early cardiomyopathic process. Interstitial space contains some lymphocytes (magnification 30×).</p> <p>Evident cardiomyopathic pattern with perivascular inflammatory infiltrations composed of lymphocytes and larger macrophages (magnification 30×).</p> <p>Myocardial tissue morphology resembles intact group specimens (magnification 30×).</p> <p>Typical cardiomyopathic pattern with numerous, dense inflammatory infiltrations with evident histiocytes, lymphocytes and other cells (magnification 30×).</p> <p>Advanced cardiomyopathy with present fibrotic focai (magnification 20×).</p> <p>Moderate cardiomyopathic pattern with lesser inflammatory infiltrations in comparison to captopril group. Regular fibrotic process (magnification 20×).</p>