Various oncogenes in triple-negative breast cancer (TNBC). Masahito Kawazu Shinya Kojima Toshihide Ueno Yasushi Totoki Hiromi Nakamura Akiko Kunita Wei Qu Jun Yoshimura Manabu Soda Takahiko Yasuda Natsuko Hama Mihoko Saito-Adachi Kazuhito Sato Shinji Kohsaka Eirin Sai Masako Ikemura Shigeru Yamamoto Tomoko Ogawa Masashi Fukayama Keiichiro Tada Yasuyuki Seto Shinichi Morishita Shoichi Hazama Tatsuhiro Shibata Yoshihiro Yamashita Hiroyuki Mano 10.1371/journal.pgen.1006853.g005 https://plos.figshare.com/articles/figure/Various_oncogenes_in_triple-negative_breast_cancer_TNBC_/5133094 <p>(<b>A</b>) NFKB1 mutations found in this study (above, TNBC) and in the TCGA data (below, various cancers). (<b>B</b>) Mutations in NOTCH1 found in this study (above, TNBC) and in the TCGA data (below, TNBC). (<b>C</b>) Mutations in ERBB2 found in this study (above, TNBC) and in the TCGA data (below, BC). (<b>D</b>) Diagram of the protein encoded by the <i>FGFR3</i>-<i>CAT</i> fusion gene. IG, immunoglobulin-like domain; TyrKc, tyrosine-protein kinase catalytic domain. (<b>E</b>) Anchorage-independent growth of 3T3 cells expressing the indicated proteins. The diagrams of the proteins in (<b>A</b>), (<b>B</b>), and (<b>C</b>) were generated using protein painter (<a href="http://explore.pediatriccancergenomeproject.org/proteinPainter" target="_blank">http://explore.pediatriccancergenomeproject.org/proteinPainter</a>). Mutations expected to be activating according to previous reports or experiments in this study are highlighted in red.</p> 2017-06-21 17:25:24 RB 1 3 T 3 mouse fibroblasts exome sequencing genome sequencing TP 53 mutations MYC driver event CpG dinucleotides Integrative analysis tandem duplication NOTCH 3 recombination pathway PTEN epidermal growth factor receptor 2. poly ADP-ribose polymerase inhibitors affinity ligands epidermal growth factor receptor BRCA 1 mutations NOTCH 2 TGFA oncogene Clonal analysis driver oncogenic events estrogen receptors tumor suppressor genes TNBC tumors recombination deficiency Triple-negative breast cancer Recurrent SVs BRCA 1 gene triple-negative breast cancer BRCA 1 promoter TGFA enhancer regions progesterone receptors KMT 2C genomic alterations TGFA enhancer region