Various oncogenes in triple-negative breast cancer (TNBC).
Masahito Kawazu
Shinya Kojima
Toshihide Ueno
Yasushi Totoki
Hiromi Nakamura
Akiko Kunita
Wei Qu
Jun Yoshimura
Manabu Soda
Takahiko Yasuda
Natsuko Hama
Mihoko Saito-Adachi
Kazuhito Sato
Shinji Kohsaka
Eirin Sai
Masako Ikemura
Shigeru Yamamoto
Tomoko Ogawa
Masashi Fukayama
Keiichiro Tada
Yasuyuki Seto
Shinichi Morishita
Shoichi Hazama
Tatsuhiro Shibata
Yoshihiro Yamashita
Hiroyuki Mano
10.1371/journal.pgen.1006853.g005
https://plos.figshare.com/articles/figure/Various_oncogenes_in_triple-negative_breast_cancer_TNBC_/5133094
<p>(<b>A</b>) NFKB1 mutations found in this study (above, TNBC) and in the TCGA data (below, various cancers). (<b>B</b>) Mutations in NOTCH1 found in this study (above, TNBC) and in the TCGA data (below, TNBC). (<b>C</b>) Mutations in ERBB2 found in this study (above, TNBC) and in the TCGA data (below, BC). (<b>D</b>) Diagram of the protein encoded by the <i>FGFR3</i>-<i>CAT</i> fusion gene. IG, immunoglobulin-like domain; TyrKc, tyrosine-protein kinase catalytic domain. (<b>E</b>) Anchorage-independent growth of 3T3 cells expressing the indicated proteins. The diagrams of the proteins in (<b>A</b>), (<b>B</b>), and (<b>C</b>) were generated using protein painter (<a href="http://explore.pediatriccancergenomeproject.org/proteinPainter" target="_blank">http://explore.pediatriccancergenomeproject.org/proteinPainter</a>). Mutations expected to be activating according to previous reports or experiments in this study are highlighted in red.</p>
2017-06-21 17:25:24
RB 1
3 T 3 mouse fibroblasts
exome sequencing
genome sequencing
TP 53 mutations
MYC
driver event
CpG dinucleotides
Integrative analysis
tandem duplication
NOTCH 3
recombination pathway
PTEN
epidermal growth factor receptor 2.
poly ADP-ribose polymerase inhibitors
affinity ligands
epidermal growth factor receptor
BRCA 1 mutations
NOTCH 2
TGFA oncogene
Clonal analysis
driver oncogenic events
estrogen receptors
tumor suppressor genes
TNBC tumors
recombination deficiency Triple-negative breast cancer
Recurrent SVs
BRCA 1 gene
triple-negative breast cancer
BRCA 1 promoter
TGFA enhancer regions
progesterone receptors
KMT 2C
genomic alterations
TGFA enhancer region