%0 Figure %A Bethea, Cynthia L. %A Mueller, Kevin %A Reddy, Arubala P. %A Kohama, Steven G. %A Urbanski, Henryk F. %D 2017 %T Histograms illustrating the expression of 3 genes encoding proteins known to be aberrant in different NDDs. %U https://plos.figshare.com/articles/figure/Histograms_illustrating_the_expression_of_3_genes_encoding_proteins_known_to_be_aberrant_in_different_NDDs_/5118580 %R 10.1371/journal.pone.0178788.g009 %2 https://plos.figshare.com/ndownloader/files/8720239 %K dorsal raphe gene expression %K macaque %K obesogenic diet %K obesity %K HT %K CRH %K estradiol %K placebo %K WSD %K E-induced gene expression %K menopausal %K WSD-fed %K DNA %K serotonin %K dorsal raphe %K DE %K protein %K Ovx %K 2.5 years %X

ADAM10 and SCNA mRNAs significantly increased with E–treatment, whereas PSEN1 mRNA significantly decreased with E-treatment in the chow-fed monkeys. The effect of E observed in the chow-fed monkeys was lost in the WSD-fed monkeys. In addition, transcript abundance was decreased by an order of magnitude for ADAM10 and PSEN1 in the WSD- compared to chow-fed monkeys. * Bonferroni posthoc p<0.001.

%I PLOS ONE