%0 Figure %A J. Operario, Darwin %A Koeppel, Alexander F. %A D. Turner, Stephen %A Bao, Yongde %A Pholwat, Suporn %A Banu, Sayera %A Foongladda, Suporn %A Mpagama, Stellah %A Gratz, Jean %A Ogarkov, Oleg %A Zhadova, Svetlana %A K. Heysell, Scott %A R. Houpt, Eric %D 2017 %T Degree of heteroresistance at major loci. %U https://plos.figshare.com/articles/figure/Degree_of_heteroresistance_at_major_loci_/5019350 %R 10.1371/journal.pone.0176522.g003 %2 https://plos.figshare.com/ndownloader/files/8486321 %K genotypic-phenotypic PZA susceptibility correlations %K codon %K multidrug-resistant tuberculosis Amplicon-based %K NGS %K resistance-associated mutation %K Generation Sequencing %K 3519 nucleotides %K level pncA heteroresistance %K MDR strains %K gene regions %K DST %K TB %K Mycobacterium tuberculosis drug susceptibility testing %K multidrug-resistant M %K generation sequencing %K 11 resistance-associated gene regions %K Heteroresistant loci %X

Loci whereby at least 5% of isolates had some degree of mutation are shown, as well as known rpoB and eis mutations. The y-axis shows the degree of heteroresistance, with each ‘X’ symbol representing a single isolate. Horizontal lines are median values. Loci are shown on the x axis. In rare instances whereby an isolate had more than one mutation at the same locus, the mutation with the highest degree of heteroresistance is shown.

%I PLOS ONE