Cagatay Bilgin, Cemal W. Lund, Amanda Can, Ali E. Plopper, George Yener, Bülent Outline of the algorithm to compute Collagen Alignment Index (CAI). <p>After segmenting the nuclei, cell-graph are built capturing the spatial distribution. Voronoi diagrams are built and the gradient vectors in each Voronoi compartment are calculated. A distribution of the angles between the cell-graph edges and the gradient vectors is calculated to find the CAI metric.</p> algorithm;compute;collagen;alignment 2013-02-20
    https://plos.figshare.com/articles/figure/_Outline_of_the_algorithm_to_compute_Collagen_Alignment_Index_CAI_/497814
10.1371/journal.pone.0012783.g007