10.1371/journal.ppat.1001139.g004 Yasuko Hatta Yasuko Hatta Karen Hershberger Karen Hershberger Kyoko Shinya Kyoko Shinya Sean C. Proll Sean C. Proll Richard R. Dubielzig Richard R. Dubielzig Masato Hatta Masato Hatta Michael G. Katze Michael G. Katze Yoshihiro Kawaoka Yoshihiro Kawaoka M. Suresh M. Suresh Apoptosis of CD8 T cells in mice infected with H5N1 viruses. Public Library of Science 2010 cd8 cells mice infected h5n1 2010-10-07 01:46:04 Figure https://plos.figshare.com/articles/figure/_Apoptosis_of_CD8_T_cells_in_mice_infected_with_H5N1_viruses_/496364 <p>A and B, BALB/c mice were infected with 18 PFU of HK483 or HK486. At the indicated days after infection, the percentages of total CD8 T cells (Panel A) and K<sup>d</sup>/NP147-specific CD8 T cells (Panel B) expressing active form of caspase-3 were determined by flow cytometry; cells in the BAL were stained with anti-CD8, K<sup>d</sup>/NP147 pentamers, and anti-active caspase-3. Panel C, C57BL/6 (+/+), Fas-deficient (Fas KO) or BIM-deficient (BIM KO) mice (nā€Š=ā€Š3) were infected with 18 PFU of HK483. On the eighth day after infection, the percentages of total CD8 T cells and of D<sup>b</sup>/PA224-specific CD8 T cells expressing active form of caspase-3 in the BAL were determined as in panels A and B above.</p>