Pressure-overload induced concentric hypertrophy and reactive fibrosis.
Vanessa Hertig
Kim Tardif
Marc Andre Meus
Natacha Duquette
Louis Villeneuve
Fanny Toussaint
Jonathan Ledoux
Angelino Calderone
10.1371/journal.pone.0176147.g001
https://plos.figshare.com/articles/figure/Pressure-overload_induced_concentric_hypertrophy_and_reactive_fibrosis_/4927475
<p>(<b>Panel A)</b> Left ventricular (LV) wall thickness, circumference, <b>(Panel B</b>) interstitial and perivascular fibrosis as determined by Masson Trichrome staining were significantly increased in suprarenal abdominal aorta constricted rats (SAC) versus sham rats. Analysis was performed on a subpopulation of SAC (n = 3) and sham (n = 4) rats and (*) denotes <i>p</i><0.05 versus sham as determined by a student’s unpaired t-test.</p>
2017-04-27 19:20:39
nestin expression
fibrotic rat heart
collagen type
calibre blood vessels
muscle α- actin staining
pro-fibrotic peptide growth factors
collagen-expressing mesenchymal cells
nestin protein levels
filament protein nestin
TGF -β 1
TGF -β 1 stimulation
collagen-immunoreactive mesenchymal cells
prolyl 4- hydroxylase
pressure-overloaded heart
phosphatidylinositol 3- kinase
Nestin protein levels
reactive fibrotic response
II
cells co-expressing nestin