10.1371/journal.pone.0176307.g002 Stefanos Aivazidis Stefanos Aivazidis Christina M. Coughlan Christina M. Coughlan Abhishek K. Rauniyar Abhishek K. Rauniyar Hua Jiang Hua Jiang L. Alexander Liggett L. Alexander Liggett Kenneth N. Maclean Kenneth N. Maclean James R. Roede James R. Roede The burden of trisomy 21 disrupts the proteostasis network in Down syndrome - Fig 2 Public Library of Science 2017 chromosome 21. Abnormalities DS protein quality control dysfunction PN proteostasis network cell viability 2017-04-21 17:30:06 Figure https://plos.figshare.com/articles/figure/The_burden_of_trisomy_21_disrupts_the_proteostasis_network_in_Down_syndrome_-_Fig_2/4901564 <p><b>LCLs from DS patients enhanced basal levels of ROS production (A) and expression of ER stress genes (B).</b> Unstimulated DS and CTL LCLs were evaluated for basal superoxide and hydrogen peroxide production using flow cytometry. These unstimulated cells were also assessed for ER stress gene expression using qRT-PCR. N = 3; * P<0.05; ** P<0.01; *** P<0.001; **** P<0.0001.</p>