Effect of LPAATβ on tumor growth in the orthotopic model of osteosarcoma.
Farbod Rastegar
Jian-Li Gao
Deana Shenaq
Qing Luo
Qiong Shi
Stephanie H. Kim
Wei Jiang
Eric R. Wagner
Enyi Huang
Yanhong Gao
Jikun Shen
Ke Yang
Bai-Cheng He
Liang Chen
Guo-Wei Zuo
Jinyong Luo
Xiaoji Luo
Yang Bi
Xing Liu
Mi Li
Ning Hu
Linyuan Wang
Gaurav Luther
Hue H. Luu
Rex C. Haydon
Tong-Chuan He
10.1371/journal.pone.0014182.g005
https://plos.figshare.com/articles/figure/_Effect_of_LPAAT_946_on_tumor_growth_in_the_orthotopic_model_of_osteosarcoma_/486011
<p><b>A</b>. Xenogen IVIS 200 bioluminescence imaging of orthotopic tumor growth. Athymic nude mice were periosteally injected at proximal tibia with 143B cells infected with AdR-LPAATβ, AdRFP, or AdR-siLPAATβ for 15 h (10<sup>6</sup> cells/injection). Animals were subjected to Xenogen imaging at the indicated time points. Representative imaging results at 37 days post injection are shown. <b>B</b>. Quantitative analysis of Xenogen imaging signal intensity (photons/sec/cm<sup>2</sup>/steradian) over the time after injection. <b>C</b>. Tumor growth as determined by tumor volume. The dimensions of injection sites were measured roughly every 3 days during the course of study. Tumor volumes (mm<sup>3</sup>) were calculated as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0014182#s2" target="_blank">Methods</a>. “*” <i>p-value <0.05</i>, “**” <i>p</i>-<i>value <0.001</i>.</p>
2013-02-20 22:06:54
orthotopic