The relationship of drd1a gene to <i>Shati/Nat8L</i> expression. Kyosuke Uno Toh Miyazaki Kengo Sodeyama Yoshiaki Miyamoto Atsumi Nitta 10.1371/journal.pone.0174196.s001 https://plos.figshare.com/articles/figure/Methamphetamine_induces_Shati_Nat8L_expression_in_the_mouse_nucleus_accumbens_via_CREB-_and_dopamine_D1_receptor-dependent_mechanism/4767595 <p>The Figure indicates that the relationship between Shati/Nat8L expression and METH effect on brain slice experiments. **<i>p</i><0.01 <i>vs</i>. aCSF. (Newman–Keuls post hoc test). (B) Dopamine D1 or D2 receptor antagonist (D1: SCH23390 10uM, D2: sulpiride 10uM) was pretreated before METH (1mM) stimulation for qPCR of Shati/Nat8L mRNA. **<i>p</i><0.01 and ***<i>p</i><0.001 <i>vs</i>., aCSF## <i>p</i><0.01 <i>vs</i>.METH. (Newman–Keuls post hoc test). (C) PC12 cells transfected with drd1a or drd2 were taken for qPCR 48 after the transfection * <i>p</i><0.05 vs pcDNA (Newman–Keuls post hoc test). Error bars represent the S.E. M</p> <p>(TIF)</p> 2017-03-20 18:04:28 mouse NAc slices METH activates CREB binding PC 12 cells mouse brain slices mouse NAc dopamine receptor signals group II mGluRs SCH mouse nucleus accumbens dopamine D 2 receptor antagonist sulpiride mRNA expression CREB activity dopamine D 1 receptor METH-induced CREB pathway dopamine D 1 receptor agonist SKF 38393 Shati mouse NAc attenuated METH-induced hyperlocomotion