The relationship of drd1a gene to <i>Shati/Nat8L</i> expression.
Kyosuke Uno
Toh Miyazaki
Kengo Sodeyama
Yoshiaki Miyamoto
Atsumi Nitta
10.1371/journal.pone.0174196.s001
https://plos.figshare.com/articles/figure/Methamphetamine_induces_Shati_Nat8L_expression_in_the_mouse_nucleus_accumbens_via_CREB-_and_dopamine_D1_receptor-dependent_mechanism/4767595
<p>The Figure indicates that the relationship between Shati/Nat8L expression and METH effect on brain slice experiments. **<i>p</i><0.01 <i>vs</i>. aCSF. (Newman–Keuls post hoc test). (B) Dopamine D1 or D2 receptor antagonist (D1: SCH23390 10uM, D2: sulpiride 10uM) was pretreated before METH (1mM) stimulation for qPCR of Shati/Nat8L mRNA. **<i>p</i><0.01 and ***<i>p</i><0.001 <i>vs</i>., aCSF## <i>p</i><0.01 <i>vs</i>.METH. (Newman–Keuls post hoc test). (C) PC12 cells transfected with drd1a or drd2 were taken for qPCR 48 after the transfection * <i>p</i><0.05 vs pcDNA (Newman–Keuls post hoc test). Error bars represent the S.E. M</p> <p>(TIF)</p>
2017-03-20 18:04:28
mouse NAc slices
METH activates CREB binding
PC 12 cells
mouse brain slices
mouse NAc
dopamine receptor signals
group II mGluRs
SCH
mouse nucleus accumbens
dopamine D 2 receptor antagonist sulpiride
mRNA
expression
CREB activity
dopamine D 1 receptor
METH-induced CREB pathway
dopamine D 1 receptor agonist SKF 38393
Shati
mouse NAc attenuated METH-induced hyperlocomotion