Kashiwadani, Hideki Kanmura, Yuichi Kuwaki, Tomoyuki Effects of acclimatization on the nociceptive response threshold evoked by calibrated forceps. <p>(A) The threshold distribution of acclimatized (open circles) and unacclimatized (filled circles) mice (<i>n</i> = 6, respectively) were plotted. (B) The mean values of the threshold were replotted. The distribution was not significantly different between the two groups (<i>t</i> = 0.6747, df = 10, <i>p</i> = 0.5152, unpaired t test). (C) The SEM values of the thresholds were replotted. The value was significantly lower in acclimatized mice (<i>t</i> = 2.700, df = 10, <i>p</i> = 0.0223, unpaired t test). Bars indicate mean ± SEM. A, acclimatized group; UA, unacclimatized group</p> time resolution;von Frey test;measurement;threshold;anti-nociceptive effects;nociception;forcep;short-acting analgesics;5 days;device;pain assays;manipulation techniques;5 minute intervals 2017-02-17
    https://plos.figshare.com/articles/figure/Effects_of_acclimatization_on_the_nociceptive_response_threshold_evoked_by_calibrated_forceps_/4666720
10.1371/journal.pone.0172461.g002