10.1371/journal.pcbi.1005284.g008
Angela F. Harper
Angela F.
Harper
Janelle B. Leuthaeuser
Janelle B.
Leuthaeuser
Patricia C. Babbitt
Patricia C.
Babbitt
John H. Morris
John
H. Morris
Thomas E. Ferrin
Thomas
E. Ferrin
Leslie B. Poole
Leslie B.
Poole
Jacquelyn S. Fetrow
Jacquelyn S.
Fetrow
PSSM Analysis subdivides Sct4 into Prx1 and Prx6 groups based on distinctive active site features.
Public Library of Science
2017
Superfamily members need
Multi-level Iterative Sequence
searches GenBank iteratively
MISST search iterations
Prx superfamily
Active Site Profile-Based Approach
Subsequent expert analysis
iterative search process
families Prx 1
Prx 6
site features
Prx superfamily members
Prx superfamily results
novel method
2017-02-10 18:25:11
Figure
https://plos.figshare.com/articles/figure/PSSM_Analysis_subdivides_Sct4_into_Prx1_and_Prx6_groups_based_on_distinctive_active_site_features_/4641409
<p>(A) A score distribution of the Sct4 Search1 results is shown with bars colored based on known functional annotation. The yellow and green boxes identify the groups distinguished by PSSM Analysis. (B) Search2 score distributions show the results of the subsequent MISST iteration, in which profiles of sequences in each of the yellow and green boxes were created and used in separate searches.</p>