10.1371/journal.pcbi.1005284.g008 Angela F. Harper Angela F. Harper Janelle B. Leuthaeuser Janelle B. Leuthaeuser Patricia C. Babbitt Patricia C. Babbitt John H. Morris John H. Morris Thomas E. Ferrin Thomas E. Ferrin Leslie B. Poole Leslie B. Poole Jacquelyn S. Fetrow Jacquelyn S. Fetrow PSSM Analysis subdivides Sct4 into Prx1 and Prx6 groups based on distinctive active site features. Public Library of Science 2017 Superfamily members need Multi-level Iterative Sequence searches GenBank iteratively MISST search iterations Prx superfamily Active Site Profile-Based Approach Subsequent expert analysis iterative search process families Prx 1 Prx 6 site features Prx superfamily members Prx superfamily results novel method 2017-02-10 18:25:11 Figure https://plos.figshare.com/articles/figure/PSSM_Analysis_subdivides_Sct4_into_Prx1_and_Prx6_groups_based_on_distinctive_active_site_features_/4641409 <p>(A) A score distribution of the Sct4 Search1 results is shown with bars colored based on known functional annotation. The yellow and green boxes identify the groups distinguished by PSSM Analysis. (B) Search2 score distributions show the results of the subsequent MISST iteration, in which profiles of sequences in each of the yellow and green boxes were created and used in separate searches.</p>