%0 DATA
%A Gabriele, Pollara
%A Matthew J., Murray
%A James M., Heather
%A Rachel, Byng-Maddick
%A Naomi, Guppy
%A Matthew, Ellis
%A Carolin T., Turner
%A Benjamin M., Chain
%A Mahdad, Noursadeghi
%D 2017
%T MDI scores predict strength of covariance between module gene expression and cell frequency in blood.
%U https://plos.figshare.com/articles/figure/MDI_scores_predict_strength_of_covariance_between_module_gene_expression_and_cell_frequency_in_blood_/4514399
%R 10.1371/journal.pone.0169271.g005
%2 https://plos.figshare.com/ndownloader/files/7307408
%K Multicellular Transcriptomic Data
%K cell type abundance
%K MDI scores
%K module gene content
%K ordinal summary statistic
%K Immune Cell Modules
%K multicellular tissue samples
%K target cell type
%K gene expression modules
%X **(A)** Relationship between geometric mean expression of two T cell modules which show highest (M14) and lowest (M4.6) covariance (shown in brackets) with T cell frequency in peripheral blood. Each data point represents measurements derived from a TST in separate individuals. Regression lines and 95% confidence limits are shown for each module. **(B-D)** The relationship between covariance of neutrophil, T cell or B cell frequencies and cell-type specific module expression, with the MDI for each module. Data points represent data derived from individual modules, giving regression lines with 95% confidence limits, Spearman rank correlation coefficients (r^{2}) and p values.