10.1371/journal.pone.0169271.g005 Gabriele Pollara Gabriele Pollara Matthew J. Murray Matthew J. Murray James M. Heather James M. Heather Rachel Byng-Maddick Rachel Byng-Maddick Naomi Guppy Naomi Guppy Matthew Ellis Matthew Ellis Carolin T. Turner Carolin T. Turner Benjamin M. Chain Benjamin M. Chain Mahdad Noursadeghi Mahdad Noursadeghi MDI scores predict strength of covariance between module gene expression and cell frequency in blood. Public Library of Science 2017 Multicellular Transcriptomic Data cell type abundance MDI scores module gene content ordinal summary statistic Immune Cell Modules multicellular tissue samples target cell type gene expression modules 2017-01-03 19:48:44 Figure https://plos.figshare.com/articles/figure/MDI_scores_predict_strength_of_covariance_between_module_gene_expression_and_cell_frequency_in_blood_/4514399 <p><b>(A)</b> Relationship between geometric mean expression of two T cell modules which show highest (M14) and lowest (M4.6) covariance (shown in brackets) with T cell frequency in peripheral blood. Each data point represents measurements derived from a TST in separate individuals. Regression lines and 95% confidence limits are shown for each module. <b>(B-D)</b> The relationship between covariance of neutrophil, T cell or B cell frequencies and cell-type specific module expression, with the MDI for each module. Data points represent data derived from individual modules, giving regression lines with 95% confidence limits, Spearman rank correlation coefficients (r<sup>2</sup>) and p values.</p>