10.1371/journal.pone.0169271.g005
Gabriele Pollara
Gabriele
Pollara
Matthew J. Murray
Matthew J.
Murray
James M. Heather
James M.
Heather
Rachel Byng-Maddick
Rachel
Byng-Maddick
Naomi Guppy
Naomi
Guppy
Matthew Ellis
Matthew
Ellis
Carolin T. Turner
Carolin T.
Turner
Benjamin M. Chain
Benjamin M.
Chain
Mahdad Noursadeghi
Mahdad
Noursadeghi
MDI scores predict strength of covariance between module gene expression and cell frequency in blood.
Public Library of Science
2017
Multicellular Transcriptomic Data
cell type abundance
MDI scores
module gene content
ordinal summary statistic
Immune Cell Modules
multicellular tissue samples
target cell type
gene expression modules
2017-01-03 19:48:44
Figure
https://plos.figshare.com/articles/figure/MDI_scores_predict_strength_of_covariance_between_module_gene_expression_and_cell_frequency_in_blood_/4514399
<p><b>(A)</b> Relationship between geometric mean expression of two T cell modules which show highest (M14) and lowest (M4.6) covariance (shown in brackets) with T cell frequency in peripheral blood. Each data point represents measurements derived from a TST in separate individuals. Regression lines and 95% confidence limits are shown for each module. <b>(B-D)</b> The relationship between covariance of neutrophil, T cell or B cell frequencies and cell-type specific module expression, with the MDI for each module. Data points represent data derived from individual modules, giving regression lines with 95% confidence limits, Spearman rank correlation coefficients (r<sup>2</sup>) and p values.</p>