10.1371/journal.pone.0168805
Merav Catalogna
Merav
Catalogna
Keren Doenyas-Barak
Keren
Doenyas-Barak
Roi Sagi
Roi
Sagi
Ramzia Abu-Hamad
Ramzia
Abu-Hamad
Uri Nevo
Uri
Nevo
Eshel Ben-Jacob
Eshel
Ben-Jacob
Shai Efrati
Shai
Efrati
Effect of Peripheral Electrical Stimulation (PES) on Nocturnal Blood Glucose in Type 2 Diabetes: A Randomized Crossover Pilot Study
Public Library of Science
2016
glucose levels
no-intervention control periods
Type 2 Diabetes
antidiabetic drug development
type 2 diabetes
hepatic glucose production
PES
Peripheral Electrical Stimulation
Randomized Crossover Pilot Study Background Regulation
T 2DM Methods
hepatic insulin sensitivity
hypothalamic-pituitary-adrenal axis modulation
glucose meter readings
Nocturnal Blood Glucose
blood glucose control
NCT
2016-12-20 21:20:51
Dataset
https://plos.figshare.com/articles/dataset/Effect_of_Peripheral_Electrical_Stimulation_PES_on_Nocturnal_Blood_Glucose_in_Type_2_Diabetes_A_Randomized_Crossover_Pilot_Study/4486766
<div><p>Background</p><p>Regulation of hepatic glucose production has been a target for antidiabetic drug development, due to its major contribution to glucose homeostasis. Previous pre-clinical study demonstrated that peripheral electrical stimulation (PES) may stimulate glucose utilization and improve hepatic insulin sensitivity. The aim of the present study was to evaluate safety, tolerability, and the glucose-lowering effect of this approach in patients with type 2 diabetes (T2DM).</p><p>Methods</p><p>Twelve patients with T2DM were recruited for an open label, interventional, randomized trial. Eleven patients underwent, in a crossover design, an active, and a no-intervention control periods, separated with a two-week washout phase. During the active period, the patients received a daily lower extremity PES treatment (1.33Hz/16Hz burst mode), for 14 days. Study endpoints included changes in glucose levels, number of hypoglycemic episodes, and other potential side effects. Endpoints were analyzed based on continuous glucose meter readings, and laboratory evaluation.</p><p>Results</p><p>We found that during the active period, the most significant effect was on nocturnal glucose control (<i>P</i> < 0.0004), as well as on pre-meal mean glucose levels (<i>P</i> < 0.02). The mean daily glucose levels were also decreased although it did not reach clinical significance (<i>P</i> = 0.07). A reduction in serum cortisol (<i>P</i> < 0.01) but not in insulin was also detected after 2 weeks of treatment. No adverse events were recorded.</p><p>Conclusions</p><p>These results indicate that repeated PES treatment, even for a very short duration, can improve blood glucose control, possibly by suppressing hepatic glucose production. This effect may be mediated via hypothalamic-pituitary-adrenal axis modulation.</p><p>Trial registration</p><p>ClinicalTrials.gov <a href="https://clinicaltrials.gov/ct2/show/NCT02727790" target="_blank">NCT02727790</a></p></div>