10.1371/journal.pone.0020832.g001
Alessandro Marsili
Alessandro
Marsili
Cristina Aguayo-Mazzucato
Cristina
Aguayo-Mazzucato
Ting Chen
Ting
Chen
Aditi Kumar
Aditi
Kumar
Mirra Chung
Mirra
Chung
Elaine P. Lunsford
Elaine
P. Lunsford
John W. Harney
John
W. Harney
Thuy Van-Tran
Thuy
Van-Tran
Elena Gianetti
Elena
Gianetti
Waile Ramadan
Waile
Ramadan
Cyril Chou
Cyril
Chou
Susan Bonner-Weir
Susan
Bonner-Weir
Philip Reed Larsen
Philip
Reed Larsen
Jorge Enrique Silva
Jorge
Enrique Silva
Ann Marie Zavacki
Ann
Marie Zavacki
Male D2KO mice weight gain and body fat on a HFD.
Public Library of Science
2011
d2ko
mice
2011-06-16 01:17:44
Figure
https://plos.figshare.com/articles/figure/_Male_D2KO_mice_weight_gain_and_body_fat_on_a_HFD_/434664
<p>(A) Body weight of wild type and D2KO mice on chow or a HFD for 6-weeks, n = 22–24 mice/genotype for HFD group, n = 5 mice/genotype for chow group. A significant interaction between genotype and diet were determined by two-way ANOVA for repeated measures (p<0.001; F = 33.55; Df = 312). After Bonferroni correction, there was a significant difference in weight gain of D2KO vs. WT after 4, 5 and 6 weeks of diet (p<0.05, 0.01 and 0.001). (B) Weight gain expressed as % of initial weight after 6 weeks on either chow or a HFD of mice shown in (A). Two-way ANOVA indicated a significant interaction between genotype and diet (2WA g×d) (p<0.05; F = 7.11; Df = 52). (C) % body fat as determined by microCT, n = 4–5 mice/group. Two-way ANOVA indicated a significant interaction between genotype and diet (p<0.05; F = 4.87; Df = 15). (D) Density of voxels falling in the Hounsfield Unit range defined for adipose tissue of a representative wild type and D2KO mouse. Red is more dense while purple is less in the colorbar range. (E) Average food intake of wild type and D2KO mice on either a chow or HFD was monitored for 7 days at 3 weeks of diet and is shown expressed as kcal/day/mouse. Two-way ANOVA indicated that diet significantly effected the overall caloric consumption independent of genotype (2WA d) (p<0.01; F = 10.25; Df = 16). When a significant interaction between genotype and diet was found individual means were compared within groups by unpaired Student's t-test. Data presented are the mean ± SEM; * = p<0.05, ** = p<0.01, *** = p<0.001, ns = not significant.</p>