Anchor insertion.
Steven M. Lewis
Brian A. Kuhlman
10.1371/journal.pone.0020872.g001
https://plos.figshare.com/articles/figure/_Anchor_insertion_/434398
<p>Panel A demonstrates the AnchoredDesign process with a simple cartoon. At left, we start with a known interaction between a target (cyan) and a natural partner (orange) with a characteristic interaction (the anchor, yellow). In the middle, we graft the anchor into the scaffold (magenta) to create a rough starting structure. At right, we fill out the scaffold-target interface with the AnchoredDesign protocol. Panel B demonstrates the process using protein structures for greater clarity (using the same color scheme).</p>
2011-06-17 01:13:18
chemistry
Computational biology
biophysics
Biochemistry