Crystal structure of HIV-1 IN<sup>Y15A,F185H</sup>•GSK1264 complex. GuptaKushol TurkkiVesa Sherrill-MixScott HwangYoung EilersGrant TaylorLouis McDanalCharlene WangPing TemelkoffDavid NolteRobert T. VelthuisenEmile JeffreyJerry D. Van DuyneGregory BushmanFrederic D. 2016 <p>(A) Shown is a simulated annealing composite-omit 2F<sub>o</sub>-F<sub>c</sub> electron density map contoured to 1.5 σ (shown in blue). Contiguous electron density is observed for the catalytic core domains, the CTDs, and GSK1264 (red), but the NTDs are disordered. (B) Simulated annealing F<sub>o</sub>-F<sub>c</sub> map density for GSK1264, contoured to 3σ (shown in blue). (C) The ALLINI-bound HIV-1 IN polymer observed in crystals. One dimer of HIV-1 IN comprises the asymmetric unit. Bound GSK1264 is shown by the red spheres, two interacting dimers are highlighted in the dotted box, and additional subunits of the open polymer are shown in light grey. (D) Cartoon of the CTD–catalytic core domain interaction, where the hand represents the CTD, the ball represents the catalytic core domain dimer, and GSK1264 is shown in red. See also <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002584#pbio.1002584.s008" target="_blank">S2 Fig and S2 Table</a>.</p>