10.1371/journal.ppat.1002124.g006
Livia Vastag
Livia
Vastag
Emre Koyuncu
Emre
Koyuncu
Sarah L. Grady
Sarah
L. Grady
Thomas E. Shenk
Thomas
E. Shenk
Joshua D. Rabinowitz
Joshua D.
Rabinowitz
Flux to pyrimidine nucleotide synthesis induced by HSV-1 infection.
Public Library of Science
2011
pyrimidine
nucleotide
synthesis
induced
hsv-1
2011-07-14 02:06:29
Figure
https://plos.figshare.com/articles/figure/_Flux_to_pyrimidine_nucleotide_synthesis_induced_by_HSV_1_infection_/427589
<p>(<b>A</b>) Schematic of carbon labeling from glutamine to UTP arising during carbon influx from glutamine to the TCA cycle. Red dots denote <sup>13</sup>C atoms originating from uniformly <sup>13</sup>C-labeled glutamine. (<b>B</b>) Plots show the levels of the labeled form of the indicated metabolites expressed as percent of the total metabolite pool. The labeling arose upon switching HSV-KOS infected or mock treated HFF cells to uniformly <sup>13</sup>C-labeled glutamine media. HCMV infected cells were switched at 48 hpi, HSV-1-infected cells at 12 hpi. The x-axis indicates time post media switch (mean ±2 s.e.; n = 2).</p>