10.1371/journal.pcbi.1002125.g003 Marc A. Marti-Renom Marc A. Marti-Renom Leonid A. Mirny Leonid A. Mirny Two computational approaches for determining the 3D structure of genomic domains and genomes. Public Library of Science 2013 computational approaches determining 3d genomic domains 2013-02-20 16:45:08 Figure https://plos.figshare.com/articles/figure/_Two_computational_approaches_for_determining_the_3D_structure_of_genomic_domains_and_genomes_/427089 <p>(A) The first approach uses polymer models to simulate relevant interactions (both physical and biological) that explain experimental observations. (B) The second approach integrates diverse experimental observations to model a conformational ensemble that satisfies the experimental observations.</p>