Norgestrel-supplemented diet significantly protects against photoreceptor cell death out to P40 in the rd10 retina.
Sarah L. Roche
Alice C. Wyse-Jackson
Violeta Gómez-Vicente
Pedro Lax
Ana M. Ruiz-Lopez
Ashleigh M. Byrne
Nicolás Cuenca
Thomas G. Cotter
10.1371/journal.pone.0165197.g001
https://plos.figshare.com/articles/figure/Norgestrel-supplemented_diet_significantly_protects_against_photoreceptor_cell_death_out_to_P40_in_the_rd10_retina_/4211085
<p><b>(A)</b> Apoptosis of retinal cells was detected by terminal dUTP nick end-labeling (TUNEL; green & greyscale) of DNA strand breaks in cell nuclei. Norgestrel treatment (NORG diet) decreased TUNEL-positive staining in the central P15 and P20 retina compared to control mice (Control diet). N = 3 mice per group. Hoechst (blue) staining reveals the cell layers in the retina. Scale bar 50μm. <b>(B)</b> Quantification of outer nuclear layer (ONL) thickness in the central and peripheral retina. N = 3 mice per group, n = 20 sections per mouse. Results are presented as mean ± SEM (t-test, *p<0.05, **p<0.01, ***p<0.005).</p>
2016-11-04 17:30:02
RP
neuroprotective
mouse models
661 W photoreceptor-like cells
photoreceptor cell loss
rd 10 microglia drive
Protective Fractalkine-CX 3CR Signaling Retinitis pigmentosa
upregulating growth factors
DAMP
RNA
rd 10 mouse
10 rd 10 pups
Norgestrel upregulates fractalkine-CX 3CR
Progesterone Attenuates Microglial-Driven Retinal Degeneration
implicating microglial changes
rd 10 retina
P 15-P rd 10 mice
rd 10 mice
cell death