%0 Figure %A Duguet, Thomas B. %A L. Charvet, Claude %A Forrester, Sean G. %A M. Wever, Claudia %A A. Dent, Joseph %A Neveu, Cedric %A N. Beech, Robin %D 2016 %T Cladogram of unc-29 copies. %U https://plos.figshare.com/articles/figure/Cladogram_of_i_unc-29_i_copies_/4015635 %R 10.1371/journal.pntd.0004826.g003 %2 https://plos.figshare.com/ndownloader/files/6468699 %K gene copies %K receptor assembly %K anthelmintic drug targets %K receptors reconstituted %K phenotype rescue %K Caenorhabditis elegans %K codon substitution rate analysis %K acetylcholine receptors %K subunits co-expressed %K Recent Duplication %K Xenopus oocytes %K nematode %K acetylcholine receptor subunit genes %K Functional Divergence %K novel drug targets %K subunit duplication %K fast-synaptic transmission %K clade V %K genome data %K Haemonchus contortus %K unc -29 %K acetylcholine receptor subunit %K acid positions %K 25 species %K receptor composition change %K subunit composition %K Parasitic Nematode Levamisole-Sensitive Acetylcholine Receptors Helminth parasites %K gene duplication %K subunit assembly %K pentameric levamisole-sensitive acetylcholine receptor %K 50 helminth genome initiative %X

This phylogeny was used to develop codon substitution models that produced the data in Table 1. Branches within the Strongyloidea, leading to the different genes are labelled A-J. Branches leading to paralogous copies are labelled yellow, those corresponding to orthologs in different species are labelled blue. See Fig 1 for species names.

%I PLOS Neglected Tropical Diseases