10.1371/journal.pone.0026021.g009 Travis J. Riedel Travis J. Riedel Lynnette C. Johnson Lynnette C. Johnson John Knight John Knight Roy R. Hantgan Roy R. Hantgan Ross P. Holmes Ross P. Holmes W. Todd Lowther W. Todd Lowther Location of mutations identified within hHOGA of PH3 patients. Public Library of Science 2011 mutations hhoga ph3 2011-10-06 02:09:16 Figure https://plos.figshare.com/articles/figure/_Location_of_mutations_identified_within_hHOGA_of_PH3_patients_/397756 <p>(A) Close-up view of one hHOGA monomer. The cartoon of the protein has been made partially transparent so that the PH3 mutations (spheres; see legend) are highlighted. The G-X-X-G-E motif is illustrated as a blue cartoon tube. The portion of the protein structure leading from the P190L variant to the active site Lys196-pyruvate adduct (stick rendering) is shown in magenta. (B) Three orthogonal views of the hHOGA tetramer illustrate the proximity of the mutations to the monomer-monomer (red dashed line) and dimer-dimer interfaces (blue dashed line). The red and blue squares indicate when an axis is projecting out toward the viewer.</p>