10.1371/journal.pone.0026021.g009
Travis J. Riedel
Travis
J. Riedel
Lynnette C. Johnson
Lynnette
C. Johnson
John Knight
John
Knight
Roy R. Hantgan
Roy R.
Hantgan
Ross P. Holmes
Ross P.
Holmes
W. Todd Lowther
W. Todd
Lowther
Location of mutations identified within hHOGA of PH3 patients.
Public Library of Science
2011
mutations
hhoga
ph3
2011-10-06 02:09:16
Figure
https://plos.figshare.com/articles/figure/_Location_of_mutations_identified_within_hHOGA_of_PH3_patients_/397756
<p>(A) Close-up view of one hHOGA monomer. The cartoon of the protein has been made partially transparent so that the PH3 mutations (spheres; see legend) are highlighted. The G-X-X-G-E motif is illustrated as a blue cartoon tube. The portion of the protein structure leading from the P190L variant to the active site Lys196-pyruvate adduct (stick rendering) is shown in magenta. (B) Three orthogonal views of the hHOGA tetramer illustrate the proximity of the mutations to the monomer-monomer (red dashed line) and dimer-dimer interfaces (blue dashed line). The red and blue squares indicate when an axis is projecting out toward the viewer.</p>