Confirmed novel PKD1 inhibitors display competitive activity with respect to ATP.
Elizabeth R. Sharlow
Gabriela Mustata Wilson
David Close
Stephanie Leimgruber
Manuj Tandon
Robyn B. Reed
Tong Ying Shun
Q. Jane Wang
Peter Wipf
John S. Lazo
10.1371/journal.pone.0025134.g003
https://plos.figshare.com/articles/figure/_Confirmed_novel_PKD1_inhibitors_display_competitive_activity_with_respect_to_ATP_/397753
<p>Select PKD1 inhibitors were evaluated to determine if they were mixed, competitive or non-competitive inhibitors of ATP. Panels A and B, representative Michaelis-Menten and Lineweaver-Burk plots of CID 5086667. This compound was found to be an ATP-competitive inhibitor. Data presented were representative of three independent experiments.</p>
2011-10-05 02:09:13
pkd1
inhibitors