Unsupervised hierarchical clustering of the expression of 451 miRNAs. Chuan Wang Shunyao Yang Gang Sun Xuying Tang Shuihua Lu Olivier Neyrolles Qian Gao 10.1371/journal.pone.0025832.g001 https://plos.figshare.com/articles/figure/_Unsupervised_hierarchical_clustering_of_the_expression_of_451_miRNAs_/396552 <p>The tree was generated by unsupervised hierarchical clustering of PBMC miRNA profiles for patients with active TB, subjects with LTBI, and healthy controls. MiRNAs with 2-fold up- or down-expression compared with the median intensity across all samples and differential expression values greater than 10% of all samples were selected for unsupervised analysis (n = 415 miRNAs). Sample clusters can be compared with the clinical parameters displayed in blocks underneath each profile. A key is provided at the bottom of the figure. Subjects' clinical status is indicated as follows: patients with active TB are indicated by red rectangles; subjects with LTBI by blue rectangles; and healthy controls by black rectangles. Age is indicated as: subjects between 15–24 years old are indicated by olive green rectangles; subjects 25–34 years old by brown rectangles; subjects 35–44 years old by purple rectangles; and subjects 45–54 years old by khaki rectangles. Females are indicated by hoar rectangles and males by darkish rectangles.</p> 2011-10-07 01:49:12 hierarchical clustering 451