10.1371/journal.pone.0151211.g001 Magdalena Zurek Magdalena Zurek Louise Sladen Louise Sladen Edvin Johansson Edvin Johansson Marita Olsson Marita Olsson Sonya Jackson Sonya Jackson Hui Zhang Hui Zhang Gaell Mayer Gaell Mayer Paul D. Hockings Paul D. Hockings Representative TI = 6000 ms image, lung density (S0<sub>air</sub>), R1<sub>air</sub>, R1<sub>O2</sub> maps of a control and PPE-challenged mouse lung. Public Library of Science 2016 MRI lung function lung density oxygen delivery OE-MRI resonance imaging method oxygen uptake region relaxation time indices ultrashort echo-time imaging sequence C 57BL mice porcine pancreatic elastase Principal Findings PPE-challenged mice PPE-challenged animals 2016-03-15 00:25:18 Figure https://plos.figshare.com/articles/figure/Representative_TI_6000_ms_image_lung_density_S0_sub_air_sub_R1_sub_air_sub_R1_sub_O2_sub_maps_of_a_control_and_PPE-challenged_mouse_lung_/3961278 <p>The maps are overlaid on TI = 6000 ms image acquired when animals were breathing air (a). ΔR1 (oxygen uptake), ΔR2* (oxygen delivery) maps for the same control and a PPE-challenged mouse (b). The challenged mouse exhibits less uniform distributions of ΔR1 and ΔR2* suggesting that the oxygen uptake and delivery to the lung were more heterogeneous. Regions of spatially matched ΔR1 and ΔR2* are indicated by arrows. Mean ΔR1 assessed in 20 bins based on ΔR2* for control (open squares) and PPE-challenged (filled squares) mice, showing excellent correlation between ΔR1 and ΔR2* (c).</p>