Non-Leukemogenic Forms of ICN Fail to Rescue 8946 Cell Line Growth and do not Transactivate <i>Myc</i>.
Jon C. Aster
Nick Bodnar
Lanwei Xu
Fredrick Karnell
John M. Milholland
Ivan Maillard
Gavin Histen
Yunsun Nam
Stephen C. Blacklow
Warren S. Pear
10.1371/journal.pone.0025645.g006
https://plos.figshare.com/articles/figure/_Non_Leukemogenic_Forms_of_ICN_Fail_to_Rescue_8946_Cell_Line_Growth_and_do_not_Transactivate_Myc_/396051
<p>(A) Comparison of rescue of 8946 cells by various ICN polypeptides following doxycycline-mediated withdrawal of <i>MYC</i>. 8946 cells were transduced with MigRI viruses, sorted for GFP positivity, and then treated with doxycycline (20 microgram/ml) for up to 8 days. Cell numbers at each time point are shown. (B, C) 8946 cells transduced as in (A) were harvested after 24 hr of treatment with doxycycline (20 microgram/ml) or vehicle (PBS). Levels of <i>Myc</i> (B) and <i>Deltex1</i> (C) mRNAs were determined by qRT-PCR.</p>
2011-10-13 01:40:51
forms
icn
8946
transactivate