10.1371/journal.pone.0157700.g003
Han Chow Chua
Han
Chow Chua
Emilie T. H. Christensen
Emilie T. H.
Christensen
Kirsten Hoestgaard-Jensen
Kirsten
Hoestgaard-Jensen
Leonny Y. Hartiadi
Leonny Y.
Hartiadi
Iqbal Ramzan
Iqbal
Ramzan
Anders A. Jensen
Anders A.
Jensen
Nathan L. Absalom
Nathan
L. Absalom
Mary Chebib
Mary
Chebib
Kavain produced greater enhancement of GABA-elicited currents at α4β2δ than at α1β2γ2L GABA<sub>A</sub>Rs.
Public Library of Science
2016
γ- Aminobutyric acid type
decrease anaesthetic sensitivity
binding assays
kavain-mediated potentiation
two-electrode voltage
R subtypes
265M
Anxiolytic Kava Extract
modulatory effect
α1β2γ2 L GABA
Functional Characteristics
Major Constituent
anxiolytic kavalactone
Xenopus oocytes
Molecular Mechanism Extracts
pepper plant
benzodiazepine binding site
Potentiates GABA
subunit composition
Piper methysticum
2016-06-22 19:56:56
Figure
https://plos.figshare.com/articles/figure/Kavain_produced_greater_enhancement_of_GABA-elicited_currents_at_4_2_than_at_1_2_2L_GABA_sub_A_sub_Rs_/3929289
<p>(A) GABA concentration-response curves in the absence (black; <i>n</i> = 10) and presence (red; <i>n</i> = 6) of 300 μM kavain at α1β2γ2L GABA<sub>A</sub>Rs. The curve parameters are summarised in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0157700#pone.0157700.t001" target="_blank">Table 1</a>. (B) GABA concentration-response curves in the absence (black; <i>n</i> = 4) and presence (red; <i>n</i> = 4) of 300 μM kavain at α4β2δ GABA<sub>A</sub>Rs. The curve parameters are summarised in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0157700#pone.0157700.t001" target="_blank">Table 1</a>. (C) Superimposed current responses of maximal GABA in the absence (black) and presence (red) of 300 μM kavain at α1β2γ2L and α4β2δ GABA<sub>A</sub>Rs. (D) The effect of kavain on the maximal GABA current responses at α1β2γ2L (<i>n</i> = 6) and α4β2δ (<i>n</i> = 7) GABA<sub>A</sub>Rs was compared using the paired <i>t</i> test, and the significance levels are indicated with n.s. (not significant) and **** (<i>p</i> < 0.0001). Data are presented as mean ± SEM.</p>