Alternate positions of conserved water molecules. Shailesh Tripathi Shruti Mathur Prashant Deshmukh Ramu Manjula Balasundaram Padmanabhan 10.1371/journal.pone.0156344.g003 https://plos.figshare.com/articles/figure/Alternate_positions_of_conserved_water_molecules_/3929283 <p><b>(A)</b> Among five conserved water molecules in the <i>apo-</i>form binding pocket, three are observed to have alternate positions. (<b>B)</b> Three out of four conserved water molecules demonstrate alternate positions in the <i>BD2-L10</i> complex. The ligand and selected residues are shown as sticks. Water molecules are shown as spheres. <b>|</b>2Fo|-|Fc| map of water molecules contoured at 1.0σ. The hydrogen bonds are shown as broken lines.</p> 2016-05-31 19:55:32 acetyl-lysine binding pocket BET family protein BRD 2 bromodomain compound BD 2 Inhibitor BRD 2-BD function NSC III BRD 2 Bromodomain NCI