%0 Figure %A R. Cox, Aaron %A Barrandon, Ornella %A Cai, Erica P. %A Rios, Jacqueline S. %A Chavez, Julia %A Bonnyman, Claire W. %A J. Lam, Carol %A Yi, Peng %A A. Melton, Douglas %A A. Kushner, Jake %D 2016 %T ANGPTL8 treatment is well tolerated in mice. %U https://plos.figshare.com/articles/figure/ANGPTL8_treatment_is_well_tolerated_in_mice_/3900903 %R 10.1371/journal.pone.0159276.g003 %2 https://plos.figshare.com/ndownloader/files/6110232 %K ANGPTL 8 %K β- cell expansion %K β- cell proliferation %K β- cell mitogenic effects %K ANGPTL 8 expression %K hematopoietic-derived cell proliferation %K β- cell identification %K β- cell quantification %K MBP %K Resolving Discrepant Findings %K maltose binding protein %K ANGPTL 8 overexpression %X

(a) Timeline indicating blood glucose sampling, EdU labeling, tail vein injection of MBP or MBP+hBT on day 1 and 2, with sacrifice on day 3. (b-c) Initial (white circles) and final (black circles) (b) body weight (g) and (c) blood glucose (mg/dl). Two-way ANOVA was performed. (d-e) Random fed serum (d) insulin (ng/ml) and (e) triglycerides (mg/dl). Data are mean ± SEM. Buffer, no EdU and buffer, EdU = 4–5 animals per group; MBP and MBP+hBT = 10 animals per group. One-way ANOVA was performed.

%I PLOS ONE