10.1371/journal.pone.0159276.g003
Aaron R. Cox
Aaron
R. Cox
Ornella Barrandon
Ornella
Barrandon
Erica P. Cai
Erica P.
Cai
Jacqueline S. Rios
Jacqueline S.
Rios
Julia Chavez
Julia
Chavez
Claire W. Bonnyman
Claire W.
Bonnyman
Carol J. Lam
Carol
J. Lam
Peng Yi
Peng
Yi
Douglas A. Melton
Douglas
A. Melton
Jake A. Kushner
Jake
A. Kushner
ANGPTL8 treatment is well tolerated in mice.
Public Library of Science
2016
ANGPTL 8
β- cell expansion
β- cell proliferation
β- cell mitogenic effects
ANGPTL 8 expression
hematopoietic-derived cell proliferation
β- cell identification
β- cell quantification
MBP
Resolving Discrepant Findings
maltose binding protein
ANGPTL 8 overexpression
2016-07-13 15:52:46
Figure
https://plos.figshare.com/articles/figure/ANGPTL8_treatment_is_well_tolerated_in_mice_/3900903
<p><b>(a)</b> Timeline indicating blood glucose sampling, EdU labeling, tail vein injection of MBP or MBP+hBT on day 1 and 2, with sacrifice on day 3. <b>(b-c)</b> Initial (white circles) and final (black circles) <b>(b)</b> body weight (g) and <b>(c)</b> blood glucose (mg/dl). Two-way ANOVA was performed. <b>(d-e)</b> Random fed serum <b>(d)</b> insulin (ng/ml) and <b>(e)</b> triglycerides (mg/dl). Data are mean ± SEM. Buffer, no EdU and buffer, EdU = 4–5 animals per group; MBP and MBP+hBT = 10 animals per group. One-way ANOVA was performed.</p>