10.1371/journal.pone.0159276.g003 Aaron R. Cox Aaron R. Cox Ornella Barrandon Ornella Barrandon Erica P. Cai Erica P. Cai Jacqueline S. Rios Jacqueline S. Rios Julia Chavez Julia Chavez Claire W. Bonnyman Claire W. Bonnyman Carol J. Lam Carol J. Lam Peng Yi Peng Yi Douglas A. Melton Douglas A. Melton Jake A. Kushner Jake A. Kushner ANGPTL8 treatment is well tolerated in mice. Public Library of Science 2016 ANGPTL 8 β- cell expansion β- cell proliferation β- cell mitogenic effects ANGPTL 8 expression hematopoietic-derived cell proliferation β- cell identification β- cell quantification MBP Resolving Discrepant Findings maltose binding protein ANGPTL 8 overexpression 2016-07-13 15:52:46 Figure https://plos.figshare.com/articles/figure/ANGPTL8_treatment_is_well_tolerated_in_mice_/3900903 <p><b>(a)</b> Timeline indicating blood glucose sampling, EdU labeling, tail vein injection of MBP or MBP+hBT on day 1 and 2, with sacrifice on day 3. <b>(b-c)</b> Initial (white circles) and final (black circles) <b>(b)</b> body weight (g) and <b>(c)</b> blood glucose (mg/dl). Two-way ANOVA was performed. <b>(d-e)</b> Random fed serum <b>(d)</b> insulin (ng/ml) and <b>(e)</b> triglycerides (mg/dl). Data are mean ± SEM. Buffer, no EdU and buffer, EdU = 4–5 animals per group; MBP and MBP+hBT = 10 animals per group. One-way ANOVA was performed.</p>