10.1371/journal.pone.0159531.g003
Kostyantyn Semenchenko
Kostyantyn
Semenchenko
Christine Wasylyk
Christine
Wasylyk
Henry Cheung
Henry
Cheung
Yves Tourrette
Yves
Tourrette
Peter Maas
Peter
Maas
Jack A Schalken
Jack
A Schalken
Gabri van der Pluijm
Gabri
van der Pluijm
Bohdan Wasylyk
Bohdan
Wasylyk
Effect of XRP44X treatment on tumorigenesis in the TRAMP prostate cancer mouse model.
Public Library of Science
2016
Mice Transcription factors
intra-cardiac injection-bone metastasis
Ra
XRP 44X
Elk 3 protein
epithelial-mesenchymal type processes
study Elk 3
prostate cancer progression
XRP 44X acts
tumour growth
models mouse models
XRP 44X in-vivo
Elk 3-like binding motifs
XRP 44X animals
2016-07-18 15:11:08
Figure
https://plos.figshare.com/articles/figure/Effect_of_XRP44X_treatment_on_tumorigenesis_in_the_TRAMP_prostate_cancer_mouse_model_/3896382
<p>Wild type (WT) and TRAMP mice were treated with XRP44X (1 mg/kg) daily, 6 days per week, from 14 to 29 weeks of age. (A, B) Genitourinary tracts (GUT) were taken as a whole (prostate, seminal vesicles, urinary bladder). Their weights relative to body weight are shown in (A) (* P = 0.031), and representative photographs are shown in (B). (C-F) The prostates were sectioned, stained with haematoxylin and eosin and dorso-lateral lobes were graded as described in [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0159531#pone.0159531.ref028" target="_blank">28</a>]. Typical sections are shown (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0159531#pone.0159531.s009" target="_blank">S2 Table</a> for overall statistics). (G) Proportion of wild type and TRAMP mice with the different prostate pathological grades or metastases after treatment with vehicle or XRP44X (NSA—no significant anomalies, PIN—prostatic intraepithelial neoplasia, WD—well differentiated adenocarcinoma, MD—medium differentiated adenocarcinoma, PD–poorly differentiated adenocarcinoma). Scale bars = 50 μm.</p>