10.1371/journal.pone.0159531.g003 Kostyantyn Semenchenko Kostyantyn Semenchenko Christine Wasylyk Christine Wasylyk Henry Cheung Henry Cheung Yves Tourrette Yves Tourrette Peter Maas Peter Maas Jack A Schalken Jack A Schalken Gabri van der Pluijm Gabri van der Pluijm Bohdan Wasylyk Bohdan Wasylyk Effect of XRP44X treatment on tumorigenesis in the TRAMP prostate cancer mouse model. Public Library of Science 2016 Mice Transcription factors intra-cardiac injection-bone metastasis Ra XRP 44X Elk 3 protein epithelial-mesenchymal type processes study Elk 3 prostate cancer progression XRP 44X acts tumour growth models mouse models XRP 44X in-vivo Elk 3-like binding motifs XRP 44X animals 2016-07-18 15:11:08 Figure https://plos.figshare.com/articles/figure/Effect_of_XRP44X_treatment_on_tumorigenesis_in_the_TRAMP_prostate_cancer_mouse_model_/3896382 <p>Wild type (WT) and TRAMP mice were treated with XRP44X (1 mg/kg) daily, 6 days per week, from 14 to 29 weeks of age. (A, B) Genitourinary tracts (GUT) were taken as a whole (prostate, seminal vesicles, urinary bladder). Their weights relative to body weight are shown in (A) (* P = 0.031), and representative photographs are shown in (B). (C-F) The prostates were sectioned, stained with haematoxylin and eosin and dorso-lateral lobes were graded as described in [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0159531#pone.0159531.ref028" target="_blank">28</a>]. Typical sections are shown (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0159531#pone.0159531.s009" target="_blank">S2 Table</a> for overall statistics). (G) Proportion of wild type and TRAMP mice with the different prostate pathological grades or metastases after treatment with vehicle or XRP44X (NSA—no significant anomalies, PIN—prostatic intraepithelial neoplasia, WD—well differentiated adenocarcinoma, MD—medium differentiated adenocarcinoma, PD–poorly differentiated adenocarcinoma). Scale bars = 50 μm.</p>