%0 Figure %A Li, Chen %A Chen, Zhongxiu %A Yang, Hao %A Luo, Fangbo %A Chen, Lihong %A Cai, Huawei %A Li, Yajiao %A You, Guiying %A Long, Dan %A Li, Shengfu %A Zhang, Qiuping %A Rao, Li %D 2016 %T The ERK inhibition effect with AZD6244 was significant in neoplastic cells and mild in non-neoplastic cells. %U https://plos.figshare.com/articles/figure/The_ERK_inhibition_effect_with_AZD6244_was_significant_in_neoplastic_cells_and_mild_in_non-neoplastic_cells_/3890634 %R 10.1371/journal.pone.0159079.g001 %2 https://plos.figshare.com/ndownloader/files/6096243 %K gene reactivation %K MEK %K May Attenuate Cardiac Hypertrophy %K ERK inhibition %K Oral Anti-Neoplastic Drug %K III %K ERK activation %K hypertrophy model %K Phase II %K Selumetinib %K LV mass increase %X

(A).Representative immunoblots using antibodies against phosphorylated ERK1/2 (pERK1/2) and total ERK1/2 (ERK1/2) to probe proteins extracted from MCF7, Colo205, 786-O, and Panc02 cell lysates treated with 50 nM, 100 nM, 200 nM, 500 nM, and 1μM AZD or without AZD, n = 3. (B).Representative immunoblots using antibodies against phosphorylated ERK1/2 (pERK1/2) and total ERK1/2 (ERK1/2) to probe proteins extracted from BRL-3A, HUVEC, fibroblasts, and H9C2 cell lysates treated with50 nM, 100 nM, 200 nM, 500 nM, and 1μM AZD or without AZD, n = 3.

%I PLOS ONE