10.1371/journal.pone.0163752.g004
Francisco Javier Pavón
Francisco
Javier Pavón
Eva María Marco
Eva María
Marco
Mariam Vázquez
Mariam
Vázquez
Laura Sánchez
Laura
Sánchez
Patricia Rivera
Patricia
Rivera
Ana Gavito
Ana
Gavito
Virginia Mela
Virginia
Mela
Francisco Alén
Francisco
Alén
Juan Decara
Juan
Decara
Juan Suárez
Juan
Suárez
Elena Giné
Elena
Giné
José Antonio López-Moreno
José Antonio
López-Moreno
Julie Chowen
Julie
Chowen
Fernando Rodríguez-de-Fonseca
Fernando
Rodríguez-de-Fonseca
Antonia Serrano
Antonia
Serrano
María Paz Viveros
María Paz
Viveros
Relative mRNA expression of endocannabinoid signaling-related proteins in the spleen of rats exposed to alcohol during adolescence and control rats grouped by sex.
Public Library of Science
2016
CB 2 expression
4- day drinking
interleukin -6 concentrations
N-acyl-phosphatidylethanolamine-specific phospholipase D expression
area-specific expression patterns
Young Adult Rats Intermittent alcohol exposure
cannabinoid receptor CB 1
ECS
adult rats
splenic endocannabinoid signaling-related proteins
Endocannabinoid Signaling-Related Proteins
alcohol-exposed rats
C-X 3-C motif
PPAR
DID
plasma pro-inflammatory cytokines
Adolescent Intermittent Alcohol Exposure
alcohol consumption
TNF
2016-09-23 17:33:52
Figure
https://plos.figshare.com/articles/figure/Relative_mRNA_expression_of_endocannabinoid_signaling-related_proteins_in_the_spleen_of_rats_exposed_to_alcohol_during_adolescence_and_control_rats_grouped_by_sex_/3857091
<p>(A) CB<sub>1</sub> mRNA levels (fold change); (B) CB<sub>2</sub> mRNA levels (fold change); (C) PPARα mRNA levels (fold change); (D) NAPE-PLD mRNA levels (fold change); (E) DGLα mRNA levels (fold change); (F) DGLβ mRNA levels (fold change); (G) FAAH mRNA levels (fold change); (H) MGL mRNA levels (fold change); and (I) FAT/CD36 mRNA levels (fold change). The bars represent means ± SEM. The data were analyzed by two-way ANOVA and significant main effects or interaction between factors was indicated as follows: (*) p<0.05 and (**) p<0.01 denote significant main effect of <i>adolescent alcohol exposure</i>; (<sup>###</sup>) p<0.001 denotes significant interaction between <i>adolescent alcohol exposure</i> and <i>sex</i>. (<sup>aaa</sup>) p<0.001 denotes significant differences compared to female control rats after <i>post hoc</i> tests; (<sup>bbb</sup>) p<0.001 denotes significant differences compared to female alcohol-exposed rats after <i>post hoc</i> tests.</p>