%0 Figure %A Lequieu, Joshua %A Chakrabarti, Anirikh %A Nayak, Satyaprakash %A Varner, Jeffrey D. %D 2011 %T Schematic of the translation initiation signaling network. %U https://plos.figshare.com/articles/figure/_Schematic_of_the_translation_initiation_signaling_network_/384444 %R 10.1371/journal.pcbi.1002263.g001 %2 https://plos.figshare.com/ndownloader/files/714085 %K initiation %K signaling %X

Growth factors trigger receptor dimerization and the formation of adaptor complexes which activate PI3K. PI3K then signals through PIP2/3 to activate Akt. Activated Akt can then activate mTORC1 either directly or by phosphorylating TSC1/2, an inhibitor of Rheb. Activated mTORC1 can phosphorylate 4EBP1 and activate S6K1, two necessary checkpoints for translation initiation. mTORC1 can also phosphorylate IRS-1, a negative feedback which inhibits formation of the adaptor complex and attenuates insulin signaling.

%I PLOS Computational Biology