Wiese, Mary Antebi, Adam Zheng, Hui Aldicarb hypersensitivity in worms during cholesterol starvation or <i>lrp-1</i> RNAi. <p>A) The second generation of worms on a cholesterol starvation diet arrest at the L1/L2 stage and are aldicarb hypersensitive. B) Worms grown on a cholesterol-free diet for one generation were tested on aldicarb as young adults. Excess cholesterol (50 µg/ml) had no effect on aldicarb sensitivity, however cholesterol starved animals are aldicarb hypersensitive. C) Worms grown on <i>lrp-1</i> RNAi also experience aldicarb hypersensitivity. Control strains for these experiments are as follows: <i>unc-32(e189)</i> - mutant for a vacuolar H<sup>+</sup>-ATPase, aldicarb resistant; <i>dgk-1(nu62)</i> - diacylglycerol kinase mutant, aldicarb hypersensitive; <i>unc-29(e1072)</i> - non-alpha subunit of the nicotinic acetylcholine receptor, aldicarb resistant. Each experiment was performed at least three times (n = 50 per strain). Error bars represent the s.e.m.</p> hypersensitivity;worms;starvation 2012-02-21
    https://plos.figshare.com/articles/figure/_Aldicarb_hypersensitivity_in_worms_during_cholesterol_starvation_or_lrp_1_RNAi_/348861
10.1371/journal.pone.0032038.g002