10.1371/journal.pone.0158599.g003
Niklas Lofruthe
Niklas
Lofruthe
Inka Gallitz
Inka
Gallitz
Lisa Traeger
Lisa
Traeger
Nicole Bäumer
Nicole
Bäumer
Isabell Schulze
Isabell
Schulze
Tanja Kuhlmann
Tanja
Kuhlmann
Carsten Müller-Tidow
Carsten
Müller-Tidow
Andrea U. Steinbicker
Andrea U.
Steinbicker
Hepatic mRNA levels of pSTAT3, MCP-1, SOD2 and activin B in the liver of WT mice after BA and intravenous iron injection.
Public Library of Science
2016
iron deficiency anemia
iron deficiency diet
BA injection
Inflammation Intravenous iron supplementation
weight iron complexes
saline 14 days
IDA
iron treatment
AI
Intravenous Iron Carboxymaltose
2016-07-12 07:11:52
Figure
https://plos.figshare.com/articles/figure/Hepatic_mRNA_levels_of_pSTAT3_MCP-1_SOD2_and_activin_B_in_the_liver_of_WT_mice_after_BA_and_intravenous_iron_injection_/3484451
<p><b>(A)</b> Phosphorylated STAT3 levels compared to α-tubulin in the liver of C57BL/6 mice 4h after intraperitoneal BA or PBS administration followed by intravenous iron or PBS treatment for an additional 2h. <b>(B)</b> Hepatic MCP-1 mRNA levels were determined in WT mice after intraperitoneal BA or PBS administration followed by intravenous iron or PBS injection for an additional 2h (n = 3, 2-way ANOVA P<0,0001; **P = 0.007: PBS/PBS vs BA/PBS; *P = 0.02: PBS/PBS vs BA/iron; **P = 0.007: PBS/iron vs BA/PBS); (*P = 0.02: PBS/iron vs BA/iron; **P = 0.008: BA/PBS vs BA/iron; not shown in the graph). <b>(C)</b> Hepatic SOD2 mRNA levels in WT mice 4h after intraperitoneal BA or PBS administration followed by intravenous iron or PBS treatment for an additional 2h (n = 3, 2-way ANOVA P = 0.0002; **P = 0.004: PBS/PBS vs BA/PBS; **P = 0.004: PBS/PBS vs BA/iron); (**P = 0.006: PBS/iron vs BA/PBS; **P = 0.007: PBS/iron vs BA/iron, not shown in graph). <b>(D)</b> Hepatic activin B mRNA levels in WT mice 4h after intraperitoneal BA or PBS administration followed by intravenous iron or PBS injection for an additional 2h (n = 3, 2-way ANOVA P<0,0001; **P = 0.009: PBS/PBS vs BA/PBS; ***P = 0.0002: PBS/PBS vs BA/iron); (**P = 0.009: PBS/iron vs BA/PBS; ***P = 0.0003: PBS/iron vs BA/iron, not shown in graph).</p>