10.1371/journal.pone.0032208.g005 Ray M. Marín Ray M. Marín Jiří Vaníček Jiří Vaníček Predictions filtered by conservation, accessibility, or both are more downregulated than non-filtered predictions. Public Library of Science 2012 filtered downregulated non-filtered 2012-02-27 01:53:18 Figure https://plos.figshare.com/articles/figure/_Predictions_filtered_by_conservation_accessibility_or_both_are_more_downregulated_than_non_filtered_predictions_/346798 <p>Mean log<sub>2</sub> fold changes in protein expression are shown for the targets of five highly conserved miRNAs, predicted using PACCMIT with different filters. The log<sub>2</sub> fold changes are taken from Selbach et al. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0032208#pone.0032208-Selbach1" target="_blank">[7]</a>. Statistical significance is given by the one-sided Wilcoxon rank sum test (*<i>P</i>≤0.05, **<i>P</i>≤0.01, ***<i>P</i>≤0.001). <i>P</i>-values>0.05 are not indicated. Error bars indicate standard errors of the mean.</p>