Tweedie, David Fukui, Koji Li, Yazhou Yu, Qian-sheng Barak, Shani Tamargo, Ian A. Rubovitch, Vardit Holloway, Harold W. Lehrmann, Elin H. Wood III, William Zhang, Yongqing Becker, Kevin G. Perez, Evelyn Van Praag, Henriette Luo, Yu J. Hoffer, Barry Becker, Robert E. G. Pick, Chaim Greig, Nigel H. CNS—neuronal canonical and non-canonical pathways observed to be regulated by mTBI compared to sham, and the effects of post-injury treatment with phenserine on mTBI-regulated pathways are presented. <p>R* refers to Reactome. Most pathways were observed to be down regulated by mTBI, with only two that were up regulated. Two pathways were associated with neurodegenerative disease: ‘Blalock Alzheimer’s Disease Up’ and ‘Biocarta Parkin Pathway’. While post-injury treatment of animals with phenserine had no effect on the majority of pathways, one Alzheimer’s disease-related pathway was further regulated by this drug. Drug treatment reversed the effects of mTBI on the Alzheimer’s disease pathway.</p> TBARS;compound;TBI;Cholinergic Mechanisms Traumatic brain injury;Concussive Mild Traumatic Brain Injury;thiobarbituric acid reactive substances;oxidative stress;Cognitive Impairments Induced;SOD;BID;hippocampal gene expression;phenserine;mTBI 2016-06-02
    https://plos.figshare.com/articles/figure/CNS_neuronal_canonical_and_non-canonical_pathways_observed_to_be_regulated_by_mTBI_compared_to_sham_and_the_effects_of_post-injury_treatment_with_phenserine_on_mTBI-regulated_pathways_are_presented_/3411457
10.1371/journal.pone.0156493.g005