10.1371/journal.pone.0156493.g005 David Tweedie David Tweedie Koji Fukui Koji Fukui Yazhou Li Yazhou Li Qian-sheng Yu Qian-sheng Yu Shani Barak Shani Barak Ian A. Tamargo Ian A. Tamargo Vardit Rubovitch Vardit Rubovitch Harold W. Holloway Harold W. Holloway Elin Lehrmann Elin Lehrmann William H. Wood III William H. Wood III Yongqing Zhang Yongqing Zhang Kevin G. Becker Kevin G. Becker Evelyn Perez Evelyn Perez Henriette Van Praag Henriette Van Praag Yu Luo Yu Luo Barry J. Hoffer Barry J. Hoffer Robert E. Becker Robert E. Becker Chaim G. Pick Chaim G. Pick Nigel H. Greig Nigel H. Greig CNS—neuronal canonical and non-canonical pathways observed to be regulated by mTBI compared to sham, and the effects of post-injury treatment with phenserine on mTBI-regulated pathways are presented. Public Library of Science 2016 TBARS compound TBI Cholinergic Mechanisms Traumatic brain injury Concussive Mild Traumatic Brain Injury thiobarbituric acid reactive substances oxidative stress Cognitive Impairments Induced SOD BID hippocampal gene expression phenserine mTBI 2016-06-02 03:45:17 Figure https://plos.figshare.com/articles/figure/CNS_neuronal_canonical_and_non-canonical_pathways_observed_to_be_regulated_by_mTBI_compared_to_sham_and_the_effects_of_post-injury_treatment_with_phenserine_on_mTBI-regulated_pathways_are_presented_/3411457 <p>R* refers to Reactome. Most pathways were observed to be down regulated by mTBI, with only two that were up regulated. Two pathways were associated with neurodegenerative disease: ‘Blalock Alzheimer’s Disease Up’ and ‘Biocarta Parkin Pathway’. While post-injury treatment of animals with phenserine had no effect on the majority of pathways, one Alzheimer’s disease-related pathway was further regulated by this drug. Drug treatment reversed the effects of mTBI on the Alzheimer’s disease pathway.</p>