10.1371/journal.pone.0156493.g005
David Tweedie
David
Tweedie
Koji Fukui
Koji
Fukui
Yazhou Li
Yazhou
Li
Qian-sheng Yu
Qian-sheng
Yu
Shani Barak
Shani
Barak
Ian A. Tamargo
Ian A.
Tamargo
Vardit Rubovitch
Vardit
Rubovitch
Harold W. Holloway
Harold W.
Holloway
Elin Lehrmann
Elin
Lehrmann
William H. Wood III
William
H. Wood III
Yongqing Zhang
Yongqing
Zhang
Kevin G. Becker
Kevin G.
Becker
Evelyn Perez
Evelyn
Perez
Henriette Van Praag
Henriette
Van Praag
Yu Luo
Yu
Luo
Barry J. Hoffer
Barry
J. Hoffer
Robert E. Becker
Robert E.
Becker
Chaim G. Pick
Chaim
G. Pick
Nigel H. Greig
Nigel H.
Greig
CNS—neuronal canonical and non-canonical pathways observed to be regulated by mTBI compared to sham, and the effects of post-injury treatment with phenserine on mTBI-regulated pathways are presented.
Public Library of Science
2016
TBARS
compound
TBI
Cholinergic Mechanisms Traumatic brain injury
Concussive Mild Traumatic Brain Injury
thiobarbituric acid reactive substances
oxidative stress
Cognitive Impairments Induced
SOD
BID
hippocampal gene expression
phenserine
mTBI
2016-06-02 03:45:17
Figure
https://plos.figshare.com/articles/figure/CNS_neuronal_canonical_and_non-canonical_pathways_observed_to_be_regulated_by_mTBI_compared_to_sham_and_the_effects_of_post-injury_treatment_with_phenserine_on_mTBI-regulated_pathways_are_presented_/3411457
<p>R* refers to Reactome. Most pathways were observed to be down regulated by mTBI, with only two that were up regulated. Two pathways were associated with neurodegenerative disease: ‘Blalock Alzheimer’s Disease Up’ and ‘Biocarta Parkin Pathway’. While post-injury treatment of animals with phenserine had no effect on the majority of pathways, one Alzheimer’s disease-related pathway was further regulated by this drug. Drug treatment reversed the effects of mTBI on the Alzheimer’s disease pathway.</p>