Minimal effects of rabbit TGF-β neutralizing antibody on aortic aneurysm.
Xiaofeng Chen
Debra L. Rateri
Deborah A. Howatt
Anju Balakrishnan
Jessica J. Moorleghen
Lisa A. Cassis
Alan Daugherty
10.1371/journal.pone.0153811.g001
https://plos.figshare.com/articles/figure/Minimal_effects_of_rabbit_TGF_neutralizing_antibody_on_aortic_aneurysm_/3197656
<p>(A) Serum TGF-β concentration was measured at termination; N = 9 in control group and n = 9–10 in TGF- β group; *denotes P<0.05 by Mann-Whitney Rank Sum Test. (B) Kaplan-Meier curves of survival. (C) Ascending aortic area and (D) suprarenal aortic diameter were measured at termination. * denotes P< 0.05 by Student’s t-test. For (A), (C) and (D) circles are individual measurements, diamonds are means, and error bars are SEM,. (E) Serum mouse anti-rabbit titers in plasma were measured at termination in mice injected with Rabbit IgG control, TGF-β antibody or vehicle (No Ab Control). Triangles are means and error bars are SEM. * denotes P<0.05, compared to no antibody control by one way ANOVA on Ranks using Student-Newman-Keuls Method.</p>
2016-04-22 06:19:27
suprarenal aortic regions
1 D 11 antibody
suprarenal aortic dilatation
TGF
Abdominal Regions AngII
Male C 57BL mice
28 days