%0 Figure %A Ward-Caviness, Cavin K. %A M. Neas, Lucas %A Blach, Colette %A Haynes, Carol S. %A LaRocque-Abramson, Karen %A Grass, Elizabeth %A Dowdy, Elaine %A Devlin, Robert B. %A Diaz-Sanchez, David %A Cascio, Wayne E. %A Miranda, Marie Lynn %A Gregory, Simon G. %A H. Shah, Svati %A E. Kraus, William %A R. Hauser, Elizabeth %D 2016 %T Flowchart displaying the analysis plan undertaken. %U https://plos.figshare.com/articles/figure/Flowchart_displaying_the_analysis_plan_undertaken_/3183064 %R 10.1371/journal.pone.0152670.g002 %2 https://plos.figshare.com/ndownloader/files/4967020 %K PAD %K SNP %K air pollution exposure %K Bone Morphogenic Protein Gene Family Modify %K eQTL P %K EA %K interaction %K BMP 8A %K traffic air pollution exposure %K bone morphogenic protein %K BMP 8A eQTLs %K gene family %K air pollution exposures %K novel gene family %K Genotype Tissue Expression Database %K AA %K variant %X

In the first step separate SNP-traffic exposure GWIS of the EA and AA cohorts was performed. Following this suggestive (P < 1x10-5) results were examined for replication via a meta-analysis of both cohorts using METAL[31]. Finally step 3 involved an examination of suggestive results from a meta-analysis of all the interactions.

%I PLOS ONE